6,6'-二溴-2,2'-联吡啶合成路线 （共 29 条）
反应条件
triethylamine; bis-triphenylphosphine-palladium(II) chloride
T=70°C; Carboxylation; esterification; P=760.051 Torr; 12 h;
参考文献
El-Ghayoury; Ziessel
Journal of Organic Chemistry, 2000 , vol. 65, # 23 p. 7757 - 7763
反应条件
1: 1.) (PPh3)2NiCl2 / 1.) Et2O, reflux, 15 min; 2.) THF, 75 min.
2: 66 percent / HBr / acetic acid / 48 h / Ambient temperature
View Scheme
参考文献
Katz, Howard Edan
Tetrahedron Letters, 1984 , vol. 25, # 43 p. 4905 - 4908
反应条件
sodium hydride in 1,4-dioxane
15 h; Heating;
参考文献
Kishii, Noriyuki; Araki, Koji; Shiraishi, Shinsaku
Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1985 , p. 373 - 378
参考文献
Burstall
Journal of the Chemical Society, 1938 , p. 1662,1669
反应条件
copper (I) cyanide
1) pyridine, 180-185 deg C, 12-14 h, 2) water, r.t.; Yield given. Multistep reaction;
参考文献
Baxter, Paul N. W.; Connor, Joseph A.; Schweizer, W. Bernd; Wallis, John D.
Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1992 , # 20 p. 3015 - 3020
反应条件
1: 6,6'-dibromo-2,2'-dipyridyl With n-butyllithium in tetrahydrofuran
Metallation;
2: carbon dioxide Carbonylation; acetylation;
参考文献
Qian, Changtao; Wang, Longcheng
Tetrahedron Letters, 2000 , vol. 41, # 13 p. 2203 - 2206
反应条件
1: biphenyl
2: HCl; water
View Scheme
参考文献
Burstall
Journal of the Chemical Society, 1938 , p. 1662,1669
反应条件
1: 6,6'-dibromo-2,2'-dipyridyl With n-butyllithium in tetrahydrofuran
T=-90°C; 0.75 h;
2: N,N-dimethyl-formamide in tetrahydrofuran
T=-80 - -30°C; Further stages.;
参考文献
Ilyashenko, Gennadiy; Choudhury, Rahela; Motevalli, Majid; Watkinson, Michael
Synlett, 2006 , # 11 p. 1759 - 1761
反应条件
n-butyllithium
1.) THF, hexane, -75 deg C, 45 min, 2.) THF, hexane, Et2O, -80 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Potts, Kevin T.; Gheysen Raiford, Kimberly A.; Keshavarz-K, Majid
Journal of the American Chemical Society, 1993 , vol. 115, # 7 p. 2793 - 2807
