1,1'-(2,2'-联吡啶-6,6'-二基)二乙酮合成路线 （共 6 条）
反应条件
tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether
T=80°C; 24 h;
参考文献
Zong, Ruifa; Wang, Dong; Hammitt, Richard; Thummel, Randolph P.
Journal of Organic Chemistry, 2006 , vol. 71, # 1 p. 167 - 175
反应条件
selenium(IV) oxide in xylene
1 h; Heating;
参考文献
Jones, Gurnos; Pitman, Mark A.; Lunt, Edward; Lythgoe, David J.; Abarca, Belen; Ballesteros, Rafael; Elmasnaouy, Mostafa
Tetrahedron, 1997 , vol. 53, # 24 p. 8257 - 8268
反应条件
1.1: n-BuLi / diethyl ether; hexane / 90 h / -78 - -40 °C
1.2: 80 percent / tetrahydrofuran; hexane / -78 - 20 °C
2.1: 57 percent / Pd(PPh3)4 / 1,2-dimethoxy-ethane / 24 h / 80 °C
View Scheme
参考文献
Zong, Ruifa; Wang, Dong; Hammitt, Richard; Thummel, Randolph P.
Journal of Organic Chemistry, 2006 , vol. 71, # 1 p. 167 - 175
反应条件
hydrogenchloride in water
T=60°C; 12 h; Inert atmosphere;
参考文献
Griffith, Gerry A.; Al-Khatib, Mohamed J.; Patel, Kalpana; Singh, Kuldip; Solan, Gregory A.
Dalton Transactions, 2009 , # 1 p. 185 - 196
反应条件
n-butyllithium
1.) THF, hexane, -75 deg C, 45 min, 2.) THF, hexane, Et2O, -80 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Potts, Kevin T.; Gheysen Raiford, Kimberly A.; Keshavarz-K, Majid
Journal of the American Chemical Society, 1993 , vol. 115, # 7 p. 2793 - 2807
反应条件
1: 50 percent Turnov. / LDA / hexane; tetrahydrofuran / 1.) -70 deg C, 9 h, 2.) room temperature, 48 h
2: 74 percent / SeO2 / xylene / 1 h / Heating
View Scheme
参考文献
Jones, Gurnos; Pitman, Mark A.; Lunt, Edward; Lythgoe, David J.; Abarca, Belen; Ballesteros, Rafael; Elmasnaouy, Mostafa
Tetrahedron, 1997 , vol. 53, # 24 p. 8257 - 8268
