3-氨基-5-氰基三氟甲苯合成路线 （共 5 条）
反应条件
1: 3-bromo-5-(trifluoromethyl)-phenylamine in DMF (N,N-dimethyl-formamide) 0.666667 h; 2: zinc cyanide With tetrakis(triphenylphosphine) palladium(0) in DMF (N,N-dimethyl-formamide) T=80°C;
参考文献
MERCK and CO., INC.
Patent: WO2004/41279 A1, 2004 ;
Location in patent: Page/Page column 173-174 ;
WO 2004/041279 A1
反应条件
acetic acid; tin(ll) chloride in ethanol; water T=80°C; 6 h;
参考文献
NOVARTIS AG; ARTMAN III, Gerald David; ELLIOTT, Jason Matthew; JI, Nan; LIU, Donglei; MA, Fupeng; MAINOLFI, Nello; MEREDITH, Erik; MIRANDA, Karl; POWERS, James J.; RAO, Chang
Patent: WO2010/66684 A2, 2010 ;
Location in patent: Page/Page column 64 ;
WO 2010/066684 A2
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=80°C; 20 h; Inert atmosphere;
参考文献
CONVERGENCE PHARMACEUTICALS LIMITED; BESWICK, Paul John; GLEAVE, Robert James; HACHISU, Shuji; VILE, Sadie; BERTHELEME, Nicolas; WARD, Simon E
Patent: WO2012/4604 A1, 2012 ;
Location in patent: Page/Page column 58-59 ;
WO 2012/004604 A1
反应条件
thionyl chloride; ammonia; trichlorophosphate in methanol; n-heptane; ethyl acetate; N,N-dimethyl-formamide; toluene
参考文献
Noro Nordisk A/S
Patent: US6503949 B1, 2003 ;
US 6503949 B1
反应条件
tert.-butylnitrite; copper(ll) bromide in acetonitrile T=0 - 65°C;
参考文献
MERCK and CO., INC.
Patent: WO2004/41279 A1, 2004 ;
Location in patent: Page/Page column 174 ;
WO 2004/041279 A1
