1: malonic acid dimethyl ester With sodium hydride in tetrahydrofuran 2: 1-(4'-chlorophenyl)-prop-2-enyl methyl carbonate With N,O-bis-(trimethylsilyl)-acetamide; hexacarbonyl molybdenum; N,N'-((1S,2S)-cyclohexane-1,2-diyl)dipicolinamide in tetrahydrofuran T=160°C; 0.1 h; microwave irradiation;

benzenesulfonamide; potassium acetate; bis(η3-allyl-μ-chloropalladium(II)) in dichloromethane T=20°C; 48 h;

N,O-bis-(trimethylsilyl)-acetamide; (1R,2R)-N,N'-bis(2-pyridinecarboxamide)-1,2-cyclohexane; hexacarbonyl molybdenum in tetrahydrofuran T=165°C; 0.1 h; microwave irradiation; Product distribution; Further Variations:Reagents;

1.1: NaH / tetrahydrofuran 1.2: 78 percent / Mo(CO)6; (S,S)-1,2-bis[(pyridin-2-yl)carbonylamino]cyclohexane; N,O-bis(trimethylsilyl)acetamide / tetrahydrofuran / 0.1 h / 160 °C / microwave irradiation 2.1: 94 percent / NaCl / dimethylsulfoxide; H2O / 0.33 h / 200 °C / microwave irradiation 3.1: ozone / CH2Cl2; methanol / 0.17 h / -78 °C 3.2: dimethyl sulfide / methanol; CH2Cl2 / 2 h / -78 - 20 °C 4.1: NaBH3CN; ammonium acetate / methanol / 18 h / 20 °C 5.1: 22 mg / 2 N NaOH / 2 h / 20 °C View Scheme