1-(环丙基甲基)哌啶-4-酮合成路线 （共 4 条）
反应条件
sodium carbonate in acetonitrile
T=85°C; 16 h;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2005/123716 A1, 2005 ;
Location in patent: Page/Page column 94-95 ;
WO 2005/123716 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 24 h;
参考文献
Shih, Charles C-Y; Kitamura, Toshio; Shi, Qian; Kawashima, Toshiyuki; Wang, Hui-Kang
Patent: US2012/46247 A1, 2012 ;
Location in patent: Page/Page column 18-19 ;
反应条件
1: 4-piperidone-monohydrite, hydrochloride With sodium carbonate
2: bromomethyl-cyclopropane in acetonitrile
T=65°C;
参考文献
Faul, Margaret M.; Grutsch, John L.; Kobierski, Michael E.; Kopach, Michael E.; Krumrich, Christine A.; Staszak, Michael A.; Udodong, Uko; Vicenzi, Jeffrey T.; Sullivan, Kevin A.
Tetrahedron, 2003 , vol. 59, # 36 p. 7215 - 7229
反应条件
1: With sodium tetrahydroborate in ethanol
T=0 - 20°C; 16 h;
2: With sodium hydroxide; water in ethanol; dichloromethane
T=20°C; 2 h;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2005/123716 A1, 2005 ;
Location in patent: Page/Page column 95 ;
WO 2005/123716 A1
