3-溴-2-氧代-2H-吡喃-5-甲腈合成路线 （共 6 条）
反应条件
1: 2-Oxo-2H-pyran-5-carboxylic acid With thionyl chloride
1 h;
2: 2-oxo-2H-pyran-5-carbonyl chloride With amidosulfamic acid
T=120°C; 1 h;
3: δ-cyano-α-pyrone With ethylene glycol dimethyl ether; pyridinium tribromide in toluene
4 h; Inert atmsphere;
参考文献
ASTRAZENECA AB
Patent: WO2004/792 A1, 2003 ;
Location in patent: Page 19 ;
反应条件
pyridinium bromide perbromide in ethylene glycol dimethyl ether; toluene
4 h; Inert atmosphereReflux;
参考文献
Ashworth; Bowden; Dembofsky; Levin; Moss; Robinson; Szczur; Virica
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 74 - 81
反应条件
1: amidosulfamic acid / 1 h / 120 °C
2: pyridinium bromide perbromide / ethylene glycol dimethyl ether; toluene / 4 h / |Inert atmosphere; |Reflux
View Scheme
参考文献
Ashworth; Bowden; Dembofsky; Levin; Moss; Robinson; Szczur; Virica
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 74 - 81
反应条件
1: thionyl chloride / 1 h / |Inert atmosphere; |Reflux
2: amidosulfamic acid / 1 h / 120 °C
3: pyridinium bromide perbromide / ethylene glycol dimethyl ether; toluene / 4 h / |Inert atmosphere; |Reflux
View Scheme
参考文献
Ashworth; Bowden; Dembofsky; Levin; Moss; Robinson; Szczur; Virica
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 74 - 81
反应条件
isopentyl nitrite; trichloroacetic acid in ethylene glycol dimethyl ether
0.5 h;
参考文献
Ashworth; Bowden; Dembofsky; Levin; Moss; Robinson; Szczur; Virica
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 74 - 81
反应条件
1.1: isopentyl nitrite; trifluoroacetic acid / ethylene glycol dimethyl ether / 0.5 h / |Reflux
2.1: hexane; tetrahydrofuran / 0.5 h / -75 °C / |Inert atmosphere
2.2: -75 - -60 °C
View Scheme
参考文献
Ashworth; Bowden; Dembofsky; Levin; Moss; Robinson; Szczur; Virica
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 74 - 81
