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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
4-溴萘-2-甲腈
合成路线
（共 14 条）
496835-91-7
4-溴萘-2-甲腈
+
109-72-8
正丁基锂
+
124-38-9
二氧化碳
→
反应条件
613-46-7
2-萘甲腈
+
33489-63-3
1-(2-萘基)-1-戊酮
+
3839-18-7
3-氰基-1-萘酸
反应条件
1: 4-bromonaphthalene-2-carbonitrile; n-butyllithium in tetrahydrofuran; hexane T=-75°C; 0.5 h; Inert atmosphere; 2: carbon dioxide in tetrahydrofuran; hexane T=-75 - -60°C; 3: With hydrogenchloride; water
参考文献
Ashworth; Bowden; Dembofsky; Levin; Moss; Robinson; Szczur; Virica
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 74 - 81
496835-91-7
4-溴萘-2-甲腈
+
109-72-8
正丁基锂
+
124-38-9
二氧化碳
→
反应条件
613-46-7
2-萘甲腈
+
33489-63-3
1-(2-萘基)-1-戊酮
+
3839-18-7
3-氰基-1-萘酸
反应条件
1: 4-bromonaphthalene-2-carbonitrile; n-butyllithium in tetrahydrofuran; hexane T=-75°C; 0.5 h; Inert atmosphere; 2: carbon dioxide in tetrahydrofuran; hexane T=-75 - -60°C; 3: With hydrogenchloride; water
参考文献
Ashworth; Bowden; Dembofsky; Levin; Moss; Robinson; Szczur; Virica
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 74 - 81
5043-29-8
1-溴-3-萘酸甲酯
→
反应条件
496835-91-7
4-溴萘-2-甲腈
反应条件
1: With dimethylaluminium amide in m-xylene T=110°C; 2 h; 2: With hydrogenchloride T=5 - 10°C; 1.5 h;
参考文献
Ashworth; Bowden; Dembofsky; Levin; Moss; Robinson; Szczur; Virica
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 74 - 81
496835-90-6
3-溴-2-氧代-2H-吡喃-5-甲腈
+
118-92-3
邻氨基苯甲酸
→
反应条件
496835-91-7
4-溴萘-2-甲腈
反应条件
isopentyl nitrite; trichloroacetic acid in ethylene glycol dimethyl ether 0.5 h;
参考文献
Ashworth; Bowden; Dembofsky; Levin; Moss; Robinson; Szczur; Virica
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 74 - 81
496835-93-9
+
5043-29-8
1-溴-3-萘酸甲酯
→
反应条件
496835-91-7
4-溴萘-2-甲腈
反应条件
1: methyl 1-bromo-3-naphthoate With potassium hydroxide in methanol; water/glacial acetic acid (1:1) 19.5 h; 2: 4-bromo-N-hydroxy-2-naphthamide With phosphorus tribromide in o-di-fluorobenzene T=25 - 85°C; 18 h;
参考文献
ASTRAZENECA AB
Patent: WO2004/792 A1, 2003 ;
Location in patent: Page 18 ;
640297-90-1
→
反应条件
496835-91-7
4-溴萘-2-甲腈
反应条件
palladium on activated charcoal T=200 - 210°C; 22 h;
参考文献
ASTRAZENECA AB
Patent: WO2004/792 A1, 2003 ;
Location in patent: Page 23 ;
496835-92-8
→
反应条件
496835-91-7
4-溴萘-2-甲腈
反应条件
thionyl chloride 18 h; Inert atmosphere;
参考文献
ASTRAZENECA AB
Patent: WO2004/792 A1, 2003 ;
Location in patent: Page 17 ;
496835-93-9
→
反应条件
496835-91-7
4-溴萘-2-甲腈
反应条件
phosphorus tribromide in o-di-fluorobenzene T=85°C; 18 h; Inert atmosphere;
参考文献
Ashworth; Bowden; Dembofsky; Levin; Moss; Robinson; Szczur; Virica
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 74 - 81
129660-12-4
2-氧代-2H-吡喃-5-甲腈
→
反应条件
496835-91-7
4-溴萘-2-甲腈
反应条件
1: pyridinium bromide perbromide / ethylene glycol dimethyl ether; toluene / 4 h / |Inert atmosphere; |Reflux 2: isopentyl nitrite; trifluoroacetic acid / ethylene glycol dimethyl ether / 0.5 h / |Reflux View Scheme
参考文献
Ashworth; Bowden; Dembofsky; Levin; Moss; Robinson; Szczur; Virica
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 74 - 81
23090-18-8
2-氧代-2H-吡喃-5-甲酰氯
→
反应条件
496835-91-7
4-溴萘-2-甲腈
反应条件
1: amidosulfamic acid / 1 h / 120 °C 2: pyridinium bromide perbromide / ethylene glycol dimethyl ether; toluene / 4 h / |Inert atmosphere; |Reflux 3: isopentyl nitrite; trifluoroacetic acid / ethylene glycol dimethyl ether / 0.5 h / |Reflux View Scheme
参考文献
Ashworth; Bowden; Dembofsky; Levin; Moss; Robinson; Szczur; Virica
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 74 - 81
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