1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; Inert atmosphere; 2: With water in tetrahydrofuran T=20°C; Inert atmosphere;

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere 1.2: 20 °C / Inert atmosphere 2.1: α,α'-azodiizobutyramidine-dihydrochloride / methanol / Reflux; Inert atmosphere 3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 4.1: hydrogenchloride; water / methanol / Reflux; Inert atmosphere View Scheme

1: α,α'-azodiizobutyramidine-dihydrochloride / methanol / Reflux; Inert atmosphere 2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 3: hydrogenchloride; water / methanol / Reflux; Inert atmosphere View Scheme

1.1: sodium hydroxide / water / 1 h / 100 °C 1.2: 20 °C 2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere 3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere 3.2: 20 °C / Inert atmosphere 4.1: α,α'-azodiizobutyramidine-dihydrochloride / methanol / Reflux; Inert atmosphere 5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 6.1: hydrogenchloride; water / methanol / Reflux; Inert atmosphere View Scheme

1.1: sodium hydroxide / water / 1 h / 100 °C 1.2: 20 °C 2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere 3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere 3.2: 20 °C / Inert atmosphere 4.1: α,α'-azodiizobutyramidine-dihydrochloride / methanol / Reflux; Inert atmosphere 5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 6.1: hydrogenchloride; water / methanol / Reflux; Inert atmosphere View Scheme

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere 2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere 2.2: 20 °C / Inert atmosphere 3.1: α,α'-azodiizobutyramidine-dihydrochloride / methanol / Reflux; Inert atmosphere 4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 5.1: hydrogenchloride; water / methanol / Reflux; Inert atmosphere View Scheme