1.1: 70 percent / Pd(Ph3P)4 / dimethylformamide / 30 h / 80 °C 2.1: 55 percent / HCO2H / Raney-Ni / 10 h / 110 °C 3.1: 90 percent / NH2OH*HCl; Na2CO3 / H2O / 2 h / 20 °C 4.1: NCS; HCl / dimethylformamide / 0.5 h / 20 °C 5.1: KN(TMS)2; Et3N / diethyl ether / 1 h / 20 °C 5.2: Et3N / acetonitrile / 3 h / 0 °C 6.1: 100 percent / TFA / 4 h / 20 °C View Scheme

tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=80°C; 30 h;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605283', constants.ctx, '0')">triethylamine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />T=0&deg;C;&nbsp;1.75&nbsp;h;&nbsp;&nbsp;Inert atmosphere;&nbsp;&nbsp;Conversion of starting material;&nbsp;<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605283', constants.ctx, '0')">triethylamine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />T=0&deg;C;&nbsp;1&nbsp;h;&nbsp;<br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '103233', constants.ctx, '0')">pyridine</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '11342940', constants.ctx, '0')">sodium hydroxide</a> <br />T=0&deg;C;&nbsp;1&nbsp;h;&nbsp;<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '4267587', constants.ctx, '0')">potassium carbonate</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />T=120&deg;C;&nbsp;0.1&nbsp;h;&nbsp;&nbsp;Inert atmosphereMicrowave irradiation;&nbsp;<br /> &nbsp;