1: With triethylamine in acetonitrile T=10 - 15°C; 2 h; Heating / reflux; 2: With hydrogenchloride; water in methanol; acetonitrile T=10 - 15°C; pH=1 - 2; 2 h; 3: With ammonia in water T=70 - 75°C; pH=7.5 - 9.0; Product distribution / selectivity;

1: in butan-1-ol T=10 - 100°C; 3 h; 2: With hydrogenchloride in methanol; butan-1-ol T=25 - 30°C; pH=1.0 - 2.0; 2 h; 3: With hydrogenchloride; ammonia Product distribution / selectivity; more than 3 stages;