1: 77 percent / methanol; H2O / 4 h / 20 °C 2: 42 percent / immobilised lipase from Pseudomonas cepacia; phosphate buffer / diisopropyl ether / 14 h / pH 7.2 3: BH3*Me2S / tetrahydrofuran / 2 h / Heating 4: K2CO3 / CH2Cl2; tetrahydrofuran / 0.5 h / 20 °C 5: 88 percent / LAH / tetrahydrofuran / 1.5 h / Heating 6: 81 percent / NaH / dimethylsulfoxide / 8 h View Scheme

1: 77 percent / methanol; H2O / 4 h / 20 °C 2: 42 percent / immobilised lipase from Pseudomonas cepacia; phosphate buffer / diisopropyl ether / 14 h / pH 7.2 3: BH3*Me2S / tetrahydrofuran / 2 h / Heating 4: K2CO3 / CH2Cl2; tetrahydrofuran / 0.5 h / 20 °C 5: 88 percent / LAH / tetrahydrofuran / 1.5 h / Heating 6: 81 percent / NaH / dimethylsulfoxide / 8 h View Scheme

1: 77 percent / methanol; H2O / 4 h / 20 °C 2: 42 percent / immobilised lipase from Pseudomonas cepacia; phosphate buffer / diisopropyl ether / 14 h / pH 7.2 3: BH3*Me2S / tetrahydrofuran / 2 h / Heating 4: K2CO3 / CH2Cl2; tetrahydrofuran / 0.5 h / 20 °C 5: 88 percent / LAH / tetrahydrofuran / 1.5 h / Heating View Scheme

1: 77 percent / methanol; H2O / 4 h / 20 °C 2: 43 percent / immobilised lipase from Pseudomonas cepacia; phosphate buffer / diisopropyl ether / 14 h / pH 7.2 3: BH3*Me2S / tetrahydrofuran / 2 h / Heating 4: K2CO3 / CH2Cl2; tetrahydrofuran / 0.5 h / 20 °C 5: 88 percent / LAH / tetrahydrofuran / 1.5 h / Heating View Scheme

halohydrin dehalogenase HheC (Agrobacterium radiobacter AD1) in N,N-dimethyl-formamide; toluene T=20°C; pH=8.1; 96 h;