1-甲基-4-苯基-4-羟基哌啶合成路线 （共 20 条）
反应条件
anschliessend mit wss. Salzsaeure;
参考文献
McElvain; Safranski
Journal of the American Chemical Society, 1950 , vol. 72, p. 3134,3135
反应条件
potassium hydroxide; sodium cyanide 1.) acetic acid / H2SO4; 2.) ethanol, reflux, 3 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Valenta, Vladimir; Protiva, Miroslav
Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 8 p. 2095 - 2106
反应条件
sulfuric acid; sodium cyanide in acetic acid 6 h;
参考文献
Valenta, Vladimir; Protiva, Miroslav
Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 8 p. 2095 - 2106
反应条件
sulfuric acid in acetonitrile T=20°C; 24 h;
参考文献
Sokolova; Cherkaev; Boiko; Moskovkin
Chemistry of Heterocyclic Compounds, 1997 , vol. 33, # 6 p. 676 - 679
反应条件
sulfuric acid T=20°C; 24 h;
参考文献
Sokolova; Cherkaev; Boiko; Moskovkin
Chemistry of Heterocyclic Compounds, 1997 , vol. 33, # 6 p. 676 - 679
反应条件
potassium hydroxide; sodium cyanide 1.) acetic acid / H2SO4; 2.) ethanol, reflux, 3 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Valenta, Vladimir; Protiva, Miroslav
Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 8 p. 2095 - 2106
参考文献
Schmidle; Mansfield
Journal of the American Chemical Society, 1955 , vol. 77, p. 5698
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Ziering et al.
Journal of Organic Chemistry, 1947 , vol. 12, p. 894,897, 9O2
参考文献
Jensen; Lundquist
Dansk Tidsskrift for Farmaci, 1943 , vol. 17, p. 173,180
反应条件
ethanol; n-heptane; nickel
T=150°C; P=95616 Torr; Hydrogenation;
参考文献
Schmidle; Mansfield
Journal of the American Chemical Society, 1955 , vol. 77, p. 5698
反应条件
in water; dimethyl sulfoxide
参考文献
BYK Gulden Lomberg Chemische Fabrik GmbH
Patent: US4333942 A1, 1982 ;
