5-溴-2-丁基-苯并呋喃合成路线 （共 6 条）
反应条件
bis(dibenzylideneacetone)-palladium(0); di-tert-butyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine in 1,4-dioxane T=100°C; 24 h; Inert atmosphere; Reagent/catalystSolvent;
参考文献
US2013/23678 A1, ;
Paragraph 0066-0067 ;
反应条件
1: potassium phosphate / copper(l) iodide; N,N-dimethylaminoacetic acid / N,N-dimethyl-formamide / Reflux 2: AlCl3, aluminium chloride / dichloromethane / 0 - 10 °C 3: sodium hydroxide / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
SANOFI; Bailly, Fréderic; Priem, Thomas; Vayron, Philippe
Patent: US2013/165673 A1, 2013 ;
反应条件
triethylamine; benzenesulfonyl chloride in water; toluene
T=80°C;
参考文献
SANOFI; Bailly, Fréderic; Priem, Thomas; Vayron, Philippe
Patent: US2013/165673 A1, 2013 ;
Location in patent: Paragraph 0055; 0056; 0057; 0058; 0059 ;
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 80 °C
2: sodium hydroxide; water / 20 - 40 °C
3: benzenesulfonyl chloride; triethylamine / toluene; water / 80 °C
View Scheme
参考文献
SANOFI; Priem, Thomas; Vayron, Philippe Paul
Patent: US2013/23678 A1, 2013 ;
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 80 °C
2: sodium hydroxide; water / 20 - 40 °C
3: benzenesulfonyl chloride; triethylamine / toluene; water / 80 °C
View Scheme
参考文献
SANOFI; Priem, Thomas; Vayron, Philippe Paul
Patent: US2013/23678 A1, 2013 ;
反应条件
1: sodium hydroxide; water / 20 - 40 °C
2: benzenesulfonyl chloride; triethylamine / toluene; water / 80 °C
View Scheme
参考文献
SANOFI; Priem, Thomas; Vayron, Philippe Paul
Patent: US2013/23678 A1, 2013 ;
