4’-甲基[1,1’-联苯]-4-甲酸甲酯合成路线 （共 47 条）
反应条件
bis(acetylacetonate)nickel(II); triphenylphosphine in tetrahydrofuran T=50°C; 1.5 h;
参考文献
Miller, Joseph A.; Farrell, Robert P.
Tetrahedron Letters, 1998 , vol. 39, # 36 p. 6441 - 6444
反应条件
1: 4,4'-dibromo biphenyl With n-butyllithium in tetrahydrofuran; hexane T=0°C; 1.58333E-05 h; flow conditions; 2: methyl iodide in tetrahydrofuran; hexane T=0°C; 0.00272222 h; flow conditions; 3: methyl chloroformate Further stages;
参考文献
Nagaki, Aiichiro; Takabayashi, Naofumi; Tomida, Yutaka; Yoshida, Jun-Ichi
Beilstein Journal of Organic Chemistry, 2009 , vol. 5, art. no. A16
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene T=110°C; Stille Cross Coupling; 12 h; Inert atmosphere;
参考文献
Qiu, Di; Meng, He; Jin, Liang; Wang, Shuai; Tang, Shengbo; Wang, Xi; Mo, Fanyang; Zhang, Yan; Wang, Jianbo
Angewandte Chemie - International Edition, 2013 , vol. 52, # 44 p. 11581 - 11584
Angew. Chem., 2013 , vol. 125, # 44 p. 11795 - 11798
反应条件
methanol in hexane; benzene Methylation;
参考文献
Santhosh; Paul; De Clercq; Pannecouque; Witvrouw; Loftus; Turpin; Buckheit, Jr.; Cushman
Journal of Medicinal Chemistry, 2001 , vol. 44, # 5 p. 703 - 714
反应条件
1.1: NaH / tetrahydrofuran / 20 °C 2.1: NiCl2(PPh3)2 / tetrahydrofuran / 0.25 h / 20 °C 2.2: 85 percent / tetrahydrofuran / 12 h / 20 °C View Scheme
参考文献
Kobayashi, Yuichi; William, Anthony D.; Mizojiri, Ryo
Journal of Organometallic Chemistry, 2002 , vol. 653, # 1-2 p. 91 - 97
反应条件
1: tert.-butylnitrite; toluene-4-sulfonic acid / 1,2-dichloro-ethane / 12 h / 20 °C / |Inert atmosphere 2: tetrakis(triphenylphosphine) palladium(0) / toluene / 12 h / 110 °C / |Inert atmosphere View Scheme
参考文献
Qiu, Di; Meng, He; Jin, Liang; Wang, Shuai; Tang, Shengbo; Wang, Xi; Mo, Fanyang; Zhang, Yan; Wang, Jianbo
Angewandte Chemie - International Edition, 2013 , vol. 52, # 44 p. 11581 - 11584
Angew. Chem., 2013 , vol. 125, # 44 p. 11795 - 11798
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; potassium phosphate; n-butyllithium; 1,1'-bis(diphenylphosphanyl)ferrocenenickel(II) chloride; potassium iodide 1.) toluene, room temperature, 30 min, 2.) toluene, 80 deg C, 16 h; Yield given. Multistep reaction;
参考文献
Ueda, Masato; Saitoh, Atsushi; Oh-tani, Saori; Miyaura, Norio
Tetrahedron, 1998 , vol. 54, # 43 p. 13079 - 13086
反应条件
boron trifluoride diethyl etherate Heating;
参考文献
Nishimura, Masato; Ueda, Masato; Miyaura, Norio
Tetrahedron, 2002 , vol. 58, # 29 p. 5779 - 5787
反应条件
NiCl2((PPh3)P)2; n-butyllithium 1.) THF, hexane, 0 deg C, 15 min, 2.) THF, hexane, 12 h, 20 deg C; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Kobayashi, Yuichi; Mizojiri, Ryo
Tetrahedron Letters, 1996 , vol. 37, # 47 p. 8531 - 8534
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate; potassium iodide 1.) DMF, 80 deg C; 2.) DME, reflux; 3.) MeOH, THF, reflux; Yield given. Multistep reaction;
参考文献
Frenette, Richard; Friesen, Richard W.
Tetrahedron Letters, 1994 , vol. 35, # 49 p. 9177 - 9180
