3-(4-氰基苯基)-3-氧代丙酸乙酯合成路线 （共 15 条）
反应条件
1: 4-cyano-benzoic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran T=20°C; 2: Mg(O2CCH2CO2Et)2 in tetrahydrofuran; acetonitrile T=20°C; Reflux;
参考文献
BIOENERGENIX
Patent: US2012/277224 A1, 2012 ;
Location in patent: Page/Page column 57 ;
US 20120277224 A1
反应条件
sodium hydride in benzene Heating;
参考文献
Gasparotto, Venusia; Castagliuolo, Ignazio; Chiarelotto, Gianfranco; Pezzi, Vincenzo; Montanaro, Daniela; Brun, Paola; Palu, Giorgio; Viola, Giampietro; Ferlin, Maria Grazia
Journal of Medicinal Chemistry, 2006 , vol. 49, # 6 p. 1910 - 1915
反应条件
niobium pentachloride in dichloromethane T=27°C; 3.5 h;
参考文献
Yadav; Subba Reddy; Eeshwaraiah; Reddy
Tetrahedron, 2005 , vol. 61, # 4 p. 875 - 878
反应条件
dichloro(cycloocta-1,5-diene)palladium(II); N,N-dicyclohexylmethylamine; triethylamine; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; magnesium chloride; [(t-Bu)3PH]BF4 in 1,4-dioxane T=80°C; P=2250.23 Torr; 18 h; Inert atmosphereGlovebox; Reagent/catalyst;
参考文献
Korsager, Signe; Nielsen, Dennis U.; Taaning, Rolf H.; Skrydstrup, Troels
Angewandte Chemie - International Edition, 2013 , vol. 52, # 37 p. 9763 - 9766
Angew. Chem., 2013 , vol. 125, # 37 p. 9945 - 9948
反应条件
in toluene 18 h; Reflux;
参考文献
Sharma, Lalima; Sattigeri, Jitendra A.; Kumar, Narest; Yadav, Ajay; Momim, Rijwan; Ahmed, Shahadat; Cliffe, Ian A.; Bhatnagar, Pradip Kumar; Ghosh, Sanjay; Raj, V. Samuel; Upadhyay, Dilip J.
Patent: US2012/108565 A1, 2012 ;
Location in patent: Paragraph 0332; 0333 ;
反应条件
BF4(1-)*C19H33ClFeN3O2P2(1+) in nitromethane T=20°C; 16 h; Inert atmosphere; chemoselective reaction;
参考文献
Alves, Luis Goncalo; Dazinger, Georg; Veiros, Luis F.; Kirchner, Karl
European Journal of Inorganic Chemistry, 2010 , # 20 p. 3160 - 3166
反应条件
n-butyronitrile; dichloro(cycloocta-1,5-diene)palladium(II); N,N-dicyclohexylmethylamine; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; magnesium chloride; [(t-Bu)3PH]BF4 in 1,4-dioxane T=80°C; 18 h; Inert atmosphereGlovebox;
参考文献
Korsager, Signe; Nielsen, Dennis U.; Taaning, Rolf H.; Skrydstrup, Troels
Angewandte Chemie - International Edition, 2013 , vol. 52, # 37 p. 9763 - 9766
Angew. Chem., 2013 , vol. 125, # 37 p. 9945 - 9948
反应条件
hydrogenchloride in water T=80°C; 1 h;
参考文献
Korsager, Signe; Nielsen, Dennis U.; Taaning, Rolf H.; Lindhardt, Anders T.; Skrydstrup, Troels
Chemistry - A European Journal, 2013 , vol. 19, # 52 p. 17687 - 17691
反应条件
sodium hydride in ethylene glycol dimethyl ether 3 h; Heating; Yield given;
参考文献
Specht, Donald P.; Martic, Peter A.; Farid, Samir; ++
Tetrahedron, 1982 , vol. 38, # 9 p. 1203 - 1211
反应条件
1: 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.24 h / 25 °C 2: ethanol / 0.2 h / |Reflux View Scheme
参考文献
Sharma, Lalima; Sattigeri, Jitendra A.; Kumar, Narest; Yadav, Ajay; Momim, Rijwan; Ahmed, Shahadat; Cliffe, Ian A.; Bhatnagar, Pradip Kumar; Ghosh, Sanjay; Raj, V. Samuel; Upadhyay, Dilip J.
Patent: US2012/108565 A1, 2012 ;
