3-(4-氰基苯基)-3-氧代丙酸乙酯合成路线 （共 15 条）
反应条件
1: Pd0(tris(tert-butyl)phosphine)2; α-cyclohexylcyclohexanemethanamine; lithium chloride / 1,4-dioxane / 16 h / 110 °C / |Inert atmosphere 2: hydrogenchloride / 1,2-dichloro-ethane / 0.25 h / 20 °C View Scheme
参考文献
Kohrt, Jeffrey T.; Conn, Ed; Maguire, Robert; Wright, Stephen W.; Singer, Robert
Tetrahedron Letters, 2013 , vol. 54, # 51 p. 7065 - 7068
参考文献
Ishida, Yohsuke; Yoshida, Yuhki; Igarashi, Tetsutaro; Sakurai, Tadamitsu
Heterocycles, 2013 , vol. 87, # 8 p. 1691 - 1698
反应条件
piperidine in ethanol
Heating;
参考文献
Specht, Donald P.; Martic, Peter A.; Farid, Samir; ++
Tetrahedron, 1982 , vol. 38, # 9 p. 1203 - 1211
反应条件
piperidine in ethanol
Heating;
参考文献
Specht, Donald P.; Martic, Peter A.; Farid, Samir; ++
Tetrahedron, 1982 , vol. 38, # 9 p. 1203 - 1211
反应条件
1: ethyl 3-(4-cyanophenyl)3-oxopropanoate With (hydroxy(tosyloxy)iodo)benzene in acetonitrile
T=20 - 80°C; 2.33333 h;
2: thiourea in acetonitrile
T=80°C; 16 h;
参考文献
Korsager, Signe; Nielsen, Dennis U.; Taaning, Rolf H.; Skrydstrup, Troels
Angewandte Chemie - International Edition, 2013 , vol. 52, # 37 p. 9763 - 9766
Angew. Chem., 2013 , vol. 125, # 37 p. 9945 - 9948
