1-甲基-3-三氟甲基-4-溴-1H-吡唑合成路线 （共 6 条）
反应条件
bromine; iron T=100°C; 4 h;
参考文献
Schlosser, Manfred; Volle, Jean-Noel; Leroux, Frederic; Schenk, Kurt
European Journal of Organic Chemistry, 2002 , # 17 p. 2913 - 2920
参考文献
Schlosser, Manfred; Volle, Jean-Noel; Leroux, Frederic; Schenk, Kurt
European Journal of Organic Chemistry, 2002 , # 17 p. 2913 - 2920
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; 2: With 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in tetrahydrofuran; hexane T=-75 - 20°C;
参考文献
WO2009/43883 A1, ;
Page/Page column 46-47 ;
WO 2009/043883 A1
反应条件
1: 4-bromo-1-methyl-3-(trifluoromethyl)pyrazole With tert.-butyl lithium in diethyl ether; pentane T=-75°C; 0.0833333 h; 2: carbon dioxide Further stages.;
参考文献
Schlosser, Manfred; Volle, Jean-Noel; Leroux, Frederic; Schenk, Kurt
European Journal of Organic Chemistry, 2002 , # 17 p. 2913 - 2920
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; 2: With 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in tetrahydrofuran; hexane T=-75 - 20°C;
参考文献
Glaxo Group Limited
Patent: WO2009/43883 A1, 2009 ;
Location in patent: Page/Page column 46-47 ;
WO 2009/043883 A1
反应条件
1: 4-bromo-1-methyl-3-(trifluoromethyl)pyrazole With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
T=-75°C; 0.0833333 h;
2: carbon dioxide Further stages.;
参考文献
Schlosser, Manfred; Volle, Jean-Noel; Leroux, Frederic; Schenk, Kurt
European Journal of Organic Chemistry, 2002 , # 17 p. 2913 - 2920
