1.1: sulfuric acid / 2.5 h / 90 - 92 °C / Inert atmosphere 1.2: 5 - 18 °C / pH 7 / Inert atmosphere 2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.27 h / 5 °C / Inert atmosphere 2.2: 0.5 h / 5 - 20 °C / Inert atmosphere View Scheme

1.1: sulfuric acid / 2.5 h / 90 - 92 °C / Inert atmosphere 1.2: 5 - 18 °C / pH 7 / Inert atmosphere 2.1: potassium tert-butylate / tetrahydrofuran / 2.33 h / 65 - 67 °C / Inert atmosphere 2.2: 3 h / 10 - 20 °C / Inert atmosphere 3.1: di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium / N,N-dimethyl-formamide / 7 h / 85 °C / Inert atmosphere 4.1: CDX-017 enzyme; pyridoxal 5'-phosphate / water; dimethyl sulfoxide / 52 h / 45 °C / pH 8.5 / Inert atmosphere; triethanolamine/isopropylamine buffer; Enzymatic reaction 4.2: 2 h / pH 6 / Inert atmosphere 5.1: sodium carbonate / isopropanol acetate; water / 0.08 h / 20 °C / Inert atmosphere 5.2: 2 h / 20 °C / Inert atmosphere 6.1: potassium carbonate / N,N-dimethyl-formamide / 2.08 h / Inert atmosphere 7.1: lithium hydroxide hydrate / tetrahydrofuran; water / 4.25 h / 15 - 20 °C / Inert atmosphere 7.2: 2 h / pH 2.5 - 3.5 / Inert atmosphere View Scheme

hydrogenchloride 2 h; Heating;