4'-羟基-3'-甲氧基苯乙酮合成路线 （共 147 条）
反应条件
1: 1-bromo-3-chloro-propane; 4'-hydroxy-3'-methoxyacetophenone With tetrabutylammomium bromide; potassium carbonate in acetonitrile T=80°C; Industry scale; 2: 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole monohydrochloride With tetrabutylammomium bromide; potassium carbonate in methanol T=60 - 65°C; autoclave;
参考文献
LUPIN LIMITED; ANSARI, Shahid, Akhtar; HIRPARA, Hitin, Maganbhai; YADAV, Ashok, Keshavlal; GIANCHANDANI, Jaya, Parasram
Patent: WO2012/164516 A1, 2012 ;
Location in patent: Page/Page column 4-5 ;
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2.1: potassium carbonate / acetonitrile / 60 - 85 °C 2.2: 0 - 30 °C 3.1: triethylamine / methanol View Scheme
参考文献
Solanki, Pavankumar V.; Uppelli, Sekhar Babu; Pandit, Bhushan S.; Mathad, Vijayavitthal T.
Organic Process Research and Development, 2014 , vol. 18, # 2 p. 342 - 348
参考文献
v.Wacek; Kratzl
Chemische Berichte, 1943 , vol. 76, p. 891,893
反应条件
isopropyl alcohol 1.5 h; Reflux;
参考文献
Synthetic Communications, , vol. 41, # 19 p. 2927 - 2931
反应条件
sodium hydroxide in 1,4-dioxane; water
参考文献
Byk Gulden Lomberg Chemische Fabrik GmbH
Patent: US4665074 A1, 1987 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20 - 50°C; 19 h;
参考文献
Qvortrup, Katrine; Nielsen, Thomas E.
Chemical Communications, 2011 , vol. 47, # 11 p. 3278 - 3280
反应条件
1: pyridine; hydroxylamine hydrochloride / dichloromethane / Reflux 2: hydrogenchloride; 10 palladium on activated charcoal / methanol; water / 15 h / 20 °C View Scheme
参考文献
Cho, Yongsung; Kim, Myeong Seop; Kim, Ho Shin; Ann, Jihyae; Lee, Jeewoo; Lee, Jiyoun; Pearce, Larry V.; Pavlyukovets, Vladimir A.; Morgan, Matthew A.; Blumberg, Peter M.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 16 p. 5227 - 5231
反应条件
1,4-dioxane; copper (II) chromite T=275°C; P=147102 Torr; Hydrogenation;
参考文献
Brewer; Cooke; Hibbert
Journal of the American Chemical Society, 1948 , vol. 70, p. 57
反应条件
1: K2CO3 / dimethylformamide / Ambient temperature 2: 93 percent / NaBH4 / methanol / 0 °C 3: 88 percent / HNO3 / 0 °C 4: 93 percent / NaOH / tetrahydrofuran; H2O / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 38, # 45 p. 7851 - 7852
反应条件
1: 97 percent / K2CO3 / dimethylformamide / 1 h / 100 °C 2: 38 percent / Br2 / CHCl3 View Scheme
参考文献
Leopold
Acta Chemica Scandinavica (1947-1973), 1950 , vol. 4, p. 1523,1533
