4'-羟基-3'-甲氧基苯乙酮合成路线 （共 147 条）
参考文献
Erdtman; Leopold
Acta Chemica Scandinavica (1947-1973), 1949 , vol. 3, p. 1358,1371
Acta Chemica Scandinavica (1947-1973), 1948 , vol. 2, p. 535
反应条件
(i) (reduction), (ii) /BRN= 3574491/, H2SO4, AcOH, EtOH; Multistep reaction;
参考文献
Forzelius,S.E. et al.
Acta Chemica Scandinavica (1947-1973), 1963 , vol. 17, p. 1470 - 1471
反应条件
sodium hydroxide; ammonium chloride; nitric acid; tetra-(n-butyl)ammonium iodide; potassium carbonate in ethanol; water; acetic acid; N,N-dimethyl-formamide
参考文献
KIRIN BEER KABUSHIKI KAISHA
Patent: EP1153920 A1, 2001 ;
反应条件
iron; potassium carbonate in dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; Petroleum ether
参考文献
Zeneca Limited; Zeneca Pharma S.A.
Patent: US6514971 B1, 2003 ;
US 6514971 B1
反应条件
nitric acid; iron; potassium carbonate in dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; Petroleum ether
参考文献
Hennequin, Laurent Francois Andre
Patent: US2003/212055 A1, 2003 ;
反应条件
1: potassium carbonate / potassium iodide / acetone / 48 h / Reflux
2: nitric acid; acetic acid / 18 h / 10 - 20 °C
3: zinc; ammonium chloride / ethanol; water / 5 h / Reflux
View Scheme
参考文献
XI, Dr. Ning
Patent: US2012/219522 A1, 2012 ;
反应条件
1: 98 percent / potassium carbonate; potassium iodide / acetonitrile / 24 h / Heating
2: 67 percent / HNO3 / acetic acid / 24 h / 20 °C
View Scheme
参考文献
MAX-PLANCK-GESELLSCHAFT ZUR FOeRDERUNG DER WISSENSCHAFTEN E.V.; ULLRICH, Axel; TORKA, Robert; ZHANG, Yixiang; KERI, Gyoergy; OeRFI, Laszlo; SZABADKAI, Istvan
Patent: WO2011/45084 A1, 2011 ;
WO 2011/045084 A1
反应条件
1: potassium carbonate
2: nitric acid
View Scheme
参考文献
Zimmermann, Mirjam; Cal, Ruben; Janett, Elia; Hoffmann, Viktor; Bochet, Christian G.; Constable, Edwin; Beaufils, Florent; Wymann, Matthias P.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 18 p. 4717 - 4720
Angew. Chem., 2014 , vol. 126, # 18 p. 4808 - 4812,5
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=25°C; 2 h;
参考文献
Crestini, Claudia; D'Auria, Maurizio
Tetrahedron, 1997 , vol. 53, # 23 p. 7877 - 7888
参考文献
Ahluwalia, V. K.; Kapur, Kanchan; Manchanda, Saroj
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 3 p. 186 - 188
