4'-羟基-3'-甲氧基苯乙酮合成路线 （共 147 条）
反应条件
triethylamine in dichloromethane
T=0°C; 0.5 h;
参考文献
Munday, Rachel H.; Martinelli, Joseph R.; Buchwald, Stephen L.
Journal of the American Chemical Society, 2008 , vol. 130, # 9 p. 2754 - 2755
反应条件
sodium hydroxide in water
参考文献
Labaz
Patent: US4134909 A1, 1979 ;
反应条件
1: 100 percent / Cs2CO3 / acetonitrile; dimethylformamide / 12 h / 20 °C
2: 90.5 percent / Pd(PPh3)4 / tetrahydrofuran / 12 h / Heating
3: 87.2 percent / bromine; HBr; acetic acid / benzene / 1.5 h / 0 °C
View Scheme
参考文献
Wang, Bowei; Vernier, Jean-Michel; Rao, Sara; Chung, Janice; Anderson, Jeffery J.; Brodkin, Jesse D.; Jiang, Xiaohui; Gardner, Michael F.; Yang, Xiaoqing; Munoz, Benito
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 1 p. 17 - 21
反应条件
in acetic acid
20 h; Heating;
参考文献
Bianchi, Mario; Butti, Alina; Christidis, Yani; Perronnet, Jacques; Barzaghi, Fernando; et al.
European Journal of Medicinal Chemistry, 1988 , vol. 23, p. 45 - 52
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20 - 75°C; 12 h;
参考文献
Wong, Chi-Huey; Burton, Dennis R.; Wilson, Ian A.
Patent: US2007/213278 A1, 2007 ;
Location in patent: Page/Page column 28; Sheet 8 ;
反应条件
potassium carbonate in water; ethyl acetate; acetone
参考文献
Burroughs Wellcome Co.
Patent: US4535183 A1, 1985 ;
反应条件
potassium hydroxide in ethanol; water
2 h;
参考文献
Ahvonen, Toivo; Brunow, Goesta; Kristersson, Per; Lundquist, Knut
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1983 , vol. 37, # 9 p. 845 - 850
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 80 °C
2: potassium hydroxide / methanol; water / 24.5 h / 0 - 20 °C
3: palladium 10 on activated carbon; hydrogen / methanol; ethyl acetate / 72 h / 20 °C
View Scheme
参考文献
Huang, Guan-Jhong; Bhaskar Reddy, M. Vijaya; Kuo, Ping-Chung; Huang, Chieh-Hung; Shih, Hung-Cheng; Lee, E.-Jian; Yang, Mei-Lin; Leu, Yann-Lii; Wu, Tian-Shung
European Journal of Medicinal Chemistry, 2012 , vol. 48, p. 371 - 378
反应条件
1: 96 percent / K2CO3 / dimethylformamide / 2 h / 25 °C
2: 52 percent / CuBr2 / ethyl acetate
3: 92 percent / K2CO3 / dimethylformamide / 2 h / 25 °C
4: 90 percent / K2CO3 / dimethylsulfoxide / 0.17 h / 25 °C
5: O2, Rose Bengal / acetonitrile / 13 °C / Irradiation
View Scheme
参考文献
Crestini, Claudia; D'Auria, Maurizio
Tetrahedron, 1997 , vol. 53, # 23 p. 7877 - 7888
反应条件
1: ethanolic sodium ethylate; copper
2: KMnO4; aqueous NaOH
3: aqueous HCl
View Scheme
参考文献
Glennie et al.
Journal of the American Chemical Society, 1955 , vol. 77, p. 2409,2410
