4'-羟基-3'-甲氧基苯乙酮合成路线 （共 147 条）
反应条件
sodium metasilicate; diethylenetriamine-N,N,N',N'',N''-pentaacetic acid; dihydrogen peroxide in various solvent(s) T=30°C; rate constant of oxidation; activation energy; other temperatures; pH 10.5; without and with heavy metal ions; Rate constantThermodynamic data;
参考文献
Gellerstedt, Goeran; Agnemo, Roland
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1980 , vol. 34, # 4 p. 275 - 280
反应条件
1.1: potassium carbonate / potassium iodide / acetone / 48 h / Reflux 2.1: nitric acid; acetic acid / 18 h / 10 - 20 °C 3.1: zinc; ammonium chloride / ethanol; water / 5 h / Reflux 4.1: sodium methylate / ethylene glycol dimethyl ether / 1 h / 0 °C 4.2: 0 - 20 °C 5.1: trichlorophosphate / 3 h / 110 °C 5.2: Cooling with ice View Scheme
参考文献
WO2011/45084 A1, ;
WO 2011/045084 A1
反应条件
potassium carbonate in acetonitrile T=20 - 80°C; 3 h;
参考文献
Kilaru, Ravendra Babu; Kuruva, Chandra Sekhar; Katla, Venkata Ramana; Chamarthi, Naga Raju
Asian Journal of Chemistry, 2013 , vol. 25, # 10 p. 5307 - 5310
反应条件
tetrabutylammomium bromide; potassium carbonate in acetonitrile T=80°C; Industry scale;
参考文献
LUPIN LIMITED; ANSARI, Shahid, Akhtar; HIRPARA, Hitin, Maganbhai; YADAV, Ashok, Keshavlal; GIANCHANDANI, Jaya, Parasram
Patent: WO2012/164516 A1, 2012 ;
Location in patent: Page/Page column 4-5 ;
参考文献
AB Ferrosan
Patent: US4366162 A1, 1982 ;
US 4366162 A
反应条件
potassium carbonate in acetone 20 h; Reflux;
参考文献
Organic Process Research and Development, , vol. 18, # 2 p. 342 - 348
反应条件
1: With TentaGel-N(R)C(O)CH2C2F4OC2F4SO2F; potassium carbonate in N,N-dimethyl-formamide T=20°C; 2: With formic acid; 1,3-bis-(diphenylphosphino)propane; triethylamine; palladium diacetate in N,N-dimethyl-formamide T=85°C; 2 h; Further stages.;
参考文献
Pan, Yijun; Holmes, Christopher P.
Organic Letters, 2001 , vol. 3, # 17 p. 2769 - 2770
反应条件
1: 73 percent / anh. potassium carbonate / ethanol / 4 h / Heating 2: 80 percent / bromine / ethanol / 2 h / Ambient temperature 3: 83 percent 4: 91 percent 5: 1.) NaBH4; 2.) H2 / 1.) dioxane; 2.) ethanol View Scheme
参考文献
Song, Qi; Wang, Feng; Xu, Jie
Chemical Communications, 2012 , vol. 48, # 56 p. 7019 - 7021
参考文献
Suh, Young Ger; Oh, Uh Taek; Kim, Hee Doo; Lee, Jee Woo; Park, Hyeung Geun; Park, Young Ho; Yi, Jung Bum
Patent: US2003/203944 A1, 2003 ;
反应条件
1H-imidazole in N,N-dimethyl-formamide 3 h; Ambient temperature;
参考文献
Wanner; Hofner
Archiv der Pharmazie, 1990 , vol. 323, # 12 p. 977 - 986
