1.1: ethyl acetate / 0 - 25 °C / Industry scale 1.2: 0 - 25 °C / Industry scale 1.3: 0 - 15 °C / pH 7 / Industry scale 2.1: hydrogenchloride / water / 12 h / 25 °C 3.1: thionyl chloride / 0 °C / Reflux 4.1: sodium hydrogencarbonate / 0.5 h / 25 °C View Scheme
参考文献
ANADYS PHARMACEUTICALS, INC.
Patent: WO2008/124450 A1, 2008 ;