反应条件
1: 98 percent / aq. K2CO3 / tetrahydrofuran / 4 h / Ambient temperature 2: 65 percent / Et3N, BOP-Cl / dimethylformamide / 16 h / Ambient temperature 3: 87 percent / LiAlH4 / tetrahydrofuran / 5 h / Ambient temperature 4: 81.5 percent / CHCl3 / 16 h / Heating 5: 100 percent / H2 / 10percent Pd/C / methanol / 24 h / 2844.3 Torr 6: 91 percent / 1 N aq. NaOH / methanol / 0.5 h / Ambient temperature View Scheme
参考文献
Klein, Scott I.; Molino, Bruce F.; Czekaj, Mark; Gardner, Charles J.; Chu, Valeria; Brown, Karen; Sabatino, Ralph D.; Bostwick, Jeffrey S.; Kasiewski, Charles; Bentley, Ross; Windisch, Vincent; Perrone, Mark; Dunwiddie, Christopher T.; Leadley, Robert J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 14 p. 2492 - 2502