2-氮杂双环[2.2.1]庚-5-烯-3-酮合成路线 （共 59 条）
反应条件
1: 90 percent / 1N HCl / H2O / 1 h / Heating
2: 98 percent / HCl / methanol / 1 h / Heating
3: 95 percent / Lithium triethylborohydride / tetrahydrofuran / 0.5 h / 0 °C
View Scheme
参考文献
Kam, Bernard L.; Oppenheimer, Norman J.
Journal of Organic Chemistry, 1981 , vol. 46, # 16 p. 3268 - 3272
反应条件
potassium hydroxide in dimethyl sulfoxide
5 h; Ambient temperature;
参考文献
Faith; Booth; Foxman; Snider
Journal of Organic Chemistry, 1985 , vol. 50, # 11 p. 1983 - 1985
反应条件
1: 5percent aq. HCl / 24 h / Ambient temperature
2: 18 h / Heating
3: pyridine / 1 h / Ambient temperature
View Scheme
参考文献
Csuk, Rene; Doerr, Petra
Tetrahedron: Asymmetry, 1994 , vol. 5, # 2 p. 269 - 276
反应条件
(i) aq. HCl, (ii) /BRN= 1098229/, (iii) /BRN= 385737/, Py; Multistep reaction;
参考文献
Daluge; Vince
Journal of Organic Chemistry, 1978 , vol. 43, # 12 p. 2311 - 2320
反应条件
1: 5percent aq. HCl / 24 h / Ambient temperature
2: 18 h / Heating
3: pyridine / 1 h / Ambient temperature
View Scheme
参考文献
Csuk, Rene; Doerr, Petra
Tetrahedron: Asymmetry, 1994 , vol. 5, # 2 p. 269 - 276
反应条件
(i) aq. HCl, (ii) /BRN= 1098229/, (iii) /BRN= 385737/, Py; Multistep reaction;
参考文献
Daluge; Vince
Journal of Organic Chemistry, 1978 , vol. 43, # 12 p. 2311 - 2320
反应条件
1: 90 percent / 1N HCl / H2O / 1 h / Heating
2: 98 percent / HCl / methanol / 1 h / Heating
3: 95 percent / Lithium triethylborohydride / tetrahydrofuran / 0.5 h / 0 °C
4: pyridine
View Scheme
参考文献
Kam, Bernard L.; Oppenheimer, Norman J.
Journal of Organic Chemistry, 1981 , vol. 46, # 16 p. 3268 - 3272
反应条件
hydrogen; palladium 10 on activated carbon in ethyl acetate
T=20°C; 24 h;
参考文献
MERCK and CO., INC.; MERCK SHARP and DOHME LIMITED
Patent: WO2003/93266 A1, 2003 ;
Location in patent: Page/Page column 26 ;
WO 03/093266 A1
反应条件
potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate in acetonitrile
3 h; Heating;
参考文献
Arjona, Odon; Csaky, Aurelio G.; Medel, Rocio; Plumet, Joaquin
Journal of Organic Chemistry, 2002 , vol. 67, # 4 p. 1380 - 1383
