4,6-二甲基-1H-吲哚-2,3-二酮合成路线 （共 14 条）
反应条件
sulfuric acid
T=80°C; 0.666667 h; Cooling with ice;
参考文献
Klein, Larry L.; Tufano, Michael D.
Tetrahedron Letters, 2013 , vol. 54, # 8 p. 1008 - 1011
反应条件
sulfuric acid
T=80°C; 0.5 h;
参考文献
RVX Therapeutics Inc.; McLure, Kevin G.; Young, Peter R.
Patent: US2013/281399 A1, 2013 ;
Location in patent: Paragraph 0696 ;
反应条件
sodium sulfate in hydrogenchloride; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; water; ethyl acetate
参考文献
State of Oregon, Acting by and through the Oregon State Board of Higher Education, Acting for and on Behalf of the Oregon Health Sciences University and the University of Oregon; Acea Pharmaceuticals, Inc.; The Regents of the University of California
Patent: US5597922 A1, 1997 ;
US 5597922 A
参考文献
Sumitomo Pharmaceuticals Co., Ltd.
Patent: US6576656 B1, 2003 ;
反应条件
4-(N,N-dimethlyamino)pyridine in xylene
Rearrangement; hydrolysis; oxidation; 8 h; Heating;
参考文献
Klasek, Antonin; Koristek, Kamil; Polis, Jiri; Kosmrlj, Janez
Tetrahedron, 2000 , vol. 56, # 11 p. 1551 - 1560
反应条件
N,N,N',N'-tetramethylguanidine in xylene
Hydrolysis; oxidation; rearrangement; 6 h; Heating;
参考文献
Klasek, Antonin; Koristek, Kamil; Polis, Jiri; Kosmrlj, Janez
Tetrahedron, 2000 , vol. 56, # 11 p. 1551 - 1560
反应条件
4-(N,N-dimethlyamino)pyridine in xylene
Hydrolysis; oxidation; rearrangement; 7 h; Heating;
参考文献
Klasek, Antonin; Koristek, Kamil; Polis, Jiri; Kosmrlj, Janez
Tetrahedron, 2000 , vol. 56, # 11 p. 1551 - 1560
反应条件
1: 79 percent / AcOOH
2: 3 percent / TMG / xylene / 6 h / Heating
View Scheme
参考文献
Klasek, Antonin; Koristek, Kamil; Polis, Jiri; Kosmrlj, Janez
Tetrahedron, 2000 , vol. 56, # 11 p. 1551 - 1560
反应条件
1: 79 percent / AcOOH
2: 1 percent / DMAP / xylene / 7 h / Heating
View Scheme
参考文献
Klasek, Antonin; Koristek, Kamil; Polis, Jiri; Kosmrlj, Janez
Tetrahedron, 2000 , vol. 56, # 11 p. 1551 - 1560
反应条件
1: 96 percent / AcOOH
2: 2 percent / DMAP / xylene / 8 h / Heating
View Scheme
参考文献
Klasek, Antonin; Koristek, Kamil; Polis, Jiri; Kosmrlj, Janez
Tetrahedron, 2000 , vol. 56, # 11 p. 1551 - 1560
