2,4-二氯-5 硝基嘧啶合成路线 （共 28 条）
反应条件
in dichloromethane 0.5 h; Ambient temperatureother solvent, temperature, reaction time; Product distribution;
参考文献
Synthetic Communications, , vol. 15, # 3 p. 171 - 178
参考文献
Bowden, Keith; Bright, Andrew C.
Journal of Chemical Research, Miniprint, 1992 , # 2 p. 514 - 539
反应条件
ammonia T=100°C; im Rohr;
参考文献
Otzen, Thomas; Wempe, Ellen G.; Kunz, Brigitte; Bartels, Rainer; Lehwark-Yvetot, Gudrun; Haensel, Wolfram; Schaper, Klaus-Juergen; Seydel, Joachim K.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 1 p. 240 - 253
参考文献
Isay
Chemische Berichte, 1906 , vol. 39, p. 252
反应条件
ammonium hydroxide; N-ethyl-N,N-diisopropylamine in dichloromethane T=-60 - 20°C; 1.5 h;
参考文献
Yang, Jiao; Wang, Li-Jiao; Liu, Jing-Jing; Zhong, Lei; Zheng, Ren-Lin; Xu, Yong; Ji, Pan; Zhang, Chun-Hui; Wang, Wen-Jing; Lin, Xing-Dong; Li, Lin-Li; Wei, Yu-Quan; Yang, Sheng-Yong
Journal of Medicinal Chemistry, 2012 , vol. 55, # 23 p. 10685 - 10699
参考文献
Isay
Chemische Berichte, 1906 , vol. 39, p. 252
反应条件
dimethyl amine; triethylamine in tetrahydrofuran
T=-78°C; 0.166667 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2005/3099 A2, 2005 ;
Location in patent: Page 136-137 ;
WO 2005/003099 A2
反应条件
1: (R)-methyl 2-(cyclopentylamino)butanoate With sodium hydrogencarbonate in cyclohexane
T=20 - 30°C; 0.5 h;
2: 2,4-Dichloro-5-nitro-pyrimidine in cyclohexane
T=60°C; 12 h; Inert atmosphere;
参考文献
SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD.
Patent: US2012/184543 A1, 2012 ;
Location in patent: Page/Page column 24 ;
反应条件
1: C10H19NO2*ClH With sodium hydrogencarbonate in cyclohexane
T=20°C; 0.25 h;
2: 2,4-Dichloro-5-nitro-pyrimidine T=20°C; 72 h;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2006/35902 A1, 2006 ;
Location in patent: Page/Page column 5; 6 ;
反应条件
1: sodium methylate; 2,4-Dichloro-5-nitro-pyrimidine in methanol
T=0°C; 0.25 h;
2: diethylamine in methanol
T=20°C;
参考文献
ELAN PHARMACEUTICALS, INC.
Patent: WO2007/8563 A2, 2007 ;
Location in patent: Page/Page column 90 ;
