1: 60 percent / aq. AcOH / 2 h / Heating 2: 90 percent / K2CO3 / dimethylformamide 3: 80 percent / H2 / 10 percent Pd(OH)2 / ethanol; tetrahydrofuran View Scheme

1.1: water; acetic acid / 2 h / Reflux 2.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / Inert atmosphere 3.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C 4.1: sodium methylate / tetrahydrofuran; methanol / 20 °C 4.2: ion-exchange resin / 0.5 h 5.1: Pearlman's catalist; hydrogen / tetrahydrofuran; ethanol / 12 h View Scheme