1: 90 percent / K2CO3 / dimethylformamide 2: 80 percent / H2 / 10 percent Pd(OH)2 / ethanol; tetrahydrofuran View Scheme

1.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / Inert atmosphere 2.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C 3.1: sodium methylate / tetrahydrofuran; methanol / 20 °C 3.2: ion-exchange resin / 0.5 h 4.1: Pearlman's catalist; hydrogen / tetrahydrofuran; ethanol / 12 h View Scheme