(S)-2-(((苄氧基)羰基)氨基)-4-((叔丁氧基羰基)氨基)丁酸合成路线 （共 7 条）
反应条件
sodium carbonate; trifluoroacetic acid 2) dioxane, 4 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Amblard, Muriel; Rodriguez, Marc; Lignon, Marie-Francoise; Galas, Marie-Christine; Bernad, Nicole; Aumelas, Andre; Martinez, Jean
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 3 p. 171 - 180
反应条件
1: With sodium hydrogencarbonate in tetrahydrofuran; water
T=20°C;
2: With hydrogenchloride in water
pH=~ 2;
参考文献
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
Patent: WO2009/18549 A1, 2009 ;
Location in patent: Page/Page column 58 ;
反应条件
sodium carbonate
T=0 - 20°C; 1.5 h;
参考文献
Huang, Hui; Martasek, Pavel; Roman, Linda J.; Masters, Bettie Sue Siler; Silverman, Richard B.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 16 p. 3147 - 3153
反应条件
sodium hydroxide in methanol
2 h; Ambient temperature;
参考文献
Amblard, Muriel; Rodriguez, Marc; Lignon, Marie-Francoise; Galas, Marie-Christine; Bernad, Nicole; Aumelas, Andre; Martinez, Jean
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 3 p. 171 - 180
反应条件
1: 40 percent / CuCO3, Cu(OH)2, 1N aq. NaHCO3 / dioxane
2: 90 percent / 1M aq. Na2CO3 / 1.5 h / 0 - 20 °C
View Scheme
参考文献
Huang, Hui; Martasek, Pavel; Roman, Linda J.; Masters, Bettie Sue Siler; Silverman, Richard B.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 16 p. 3147 - 3153
反应条件
1: <bis(trifluoroacetoxy)iodo>benzene / acetonitrile; H2O / 144 h / Ambient temperature
2: DIEA / dioxane / 3 h / Ambient temperature
3: 78 percent / 1 N NaOH / methanol / 2 h / Ambient temperature
View Scheme
参考文献
Amblard, Muriel; Rodriguez, Marc; Lignon, Marie-Francoise; Galas, Marie-Christine; Bernad, Nicole; Aumelas, Andre; Martinez, Jean
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 3 p. 171 - 180
反应条件
1: DIEA / dioxane / 3 h / Ambient temperature
2: 78 percent / 1 N NaOH / methanol / 2 h / Ambient temperature
View Scheme
参考文献
Amblard, Muriel; Rodriguez, Marc; Lignon, Marie-Francoise; Galas, Marie-Christine; Bernad, Nicole; Aumelas, Andre; Martinez, Jean
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 3 p. 171 - 180
