5-[4-(苄氧基)苄基]-2,4-嘧啶二胺合成路线 （共 10 条）
反应条件
hydrogen; acetic acid; palladium on activated charcoal T=90 - 100°C; P=2327.2 Torr;
参考文献
Roth; Rauckman; Ferone; Baccanari; Champness; Hyde
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 348 - 356
反应条件
sodium methylate in ethanol
24 h; Heating;
参考文献
Hachtel; Haller; Seydel
Arzneimittel-Forschung/Drug Research, 1988 , vol. 38, # 12 p. 1778 - 1783
反应条件
potassium carbonate in ethanol
18 h; Heating;
参考文献
Pez, Didier; Leal, Isabel; Zuccotto, Fabio; Boussard, Cyrille; Brun, Reto; Croft, Simon L.; Yardley, Vanessa; Ruiz Perez, Luis M.; Gonzalez Pacanowska, Dolores; Gilbert, Ian H.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4693 - 4711
反应条件
1: Na-methylate / dimethylsulfoxide / 0.5 h / 65 - 75 °C
2: HCl cc. / propan-2-ol / 1 h / Heating
3: 96 percent / Na-methylate / ethanol / 24 h / Heating
View Scheme
参考文献
Hachtel; Haller; Seydel
Arzneimittel-Forschung/Drug Research, 1988 , vol. 38, # 12 p. 1778 - 1783
反应条件
1.1: 71 percent / NaOEt / ethanol / 24 h / Heating
2.1: NaOEt / ethanol / 0.08 h
2.2: 32 percent / ethanol / 24 h / Heating
3.1: 100 percent / hydrochloric acid / methanol / 2 h / 20 °C
4.1: 79 percent / K2CO3 / ethanol / 18 h / Heating
View Scheme
参考文献
Pez, Didier; Leal, Isabel; Zuccotto, Fabio; Boussard, Cyrille; Brun, Reto; Croft, Simon L.; Yardley, Vanessa; Ruiz Perez, Luis M.; Gonzalez Pacanowska, Dolores; Gilbert, Ian H.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4693 - 4711
反应条件
1.1: 100 percent / pyridinium p-toluenesulfonate / CH2Cl2 / 1.5 h / 20 °C
2.1: 71 percent / NaOEt / ethanol / 24 h / Heating
3.1: NaOEt / ethanol / 0.08 h
3.2: 32 percent / ethanol / 24 h / Heating
4.1: 100 percent / hydrochloric acid / methanol / 2 h / 20 °C
5.1: 79 percent / K2CO3 / ethanol / 18 h / Heating
View Scheme
参考文献
Pez, Didier; Leal, Isabel; Zuccotto, Fabio; Boussard, Cyrille; Brun, Reto; Croft, Simon L.; Yardley, Vanessa; Ruiz Perez, Luis M.; Gonzalez Pacanowska, Dolores; Gilbert, Ian H.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4693 - 4711
反应条件
1.1: NaOEt / ethanol / 0.08 h
1.2: 32 percent / ethanol / 24 h / Heating
2.1: 100 percent / hydrochloric acid / methanol / 2 h / 20 °C
3.1: 79 percent / K2CO3 / ethanol / 18 h / Heating
View Scheme
参考文献
Pez, Didier; Leal, Isabel; Zuccotto, Fabio; Boussard, Cyrille; Brun, Reto; Croft, Simon L.; Yardley, Vanessa; Ruiz Perez, Luis M.; Gonzalez Pacanowska, Dolores; Gilbert, Ian H.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4693 - 4711
反应条件
1: 100 percent / hydrochloric acid / methanol / 2 h / 20 °C
2: 79 percent / K2CO3 / ethanol / 18 h / Heating
View Scheme
参考文献
Pez, Didier; Leal, Isabel; Zuccotto, Fabio; Boussard, Cyrille; Brun, Reto; Croft, Simon L.; Yardley, Vanessa; Ruiz Perez, Luis M.; Gonzalez Pacanowska, Dolores; Gilbert, Ian H.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4693 - 4711
反应条件
1: HCl cc. / propan-2-ol / 1 h / Heating
2: 96 percent / Na-methylate / ethanol / 24 h / Heating
View Scheme
参考文献
Hachtel; Haller; Seydel
Arzneimittel-Forschung/Drug Research, 1988 , vol. 38, # 12 p. 1778 - 1783
反应条件
in ethanol; dimethyl sulfoxide
参考文献
Sirichaiwat, Chawanee; Intaraudom, Chakapong; Kamchonwongpaisan, Sumalee; Vanichtanankul, Jarunee; Thebtaranonth, Yodhathai; Yuthavong, Yongyuth
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 345 - 354
