4-羟基吡啶-2,6-二甲酸合成路线 （共 47 条）
参考文献
Arndt; Kalischek
Chemische Berichte, 1930 , vol. 63, p. 587,593
Full Text Show Details
Arndt
Chemische Berichte, 1932 , vol. 65, p. 92
反应条件
phosphoric acid T=180°C; 4 h;
参考文献
Yuan, Ling-Zhi; Ge, Qiang; Zhao, Xiao-Fei; Ouyang, Yan; Li, Shao-Hua; Xie, Cheng-Zhi; Xu, Jing-Yuan
Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry, 2014 , vol. 44, # 8 p. 1175 - 1182
反应条件
1: PBr5 / CCl4 2: 90 percent / NH2NH2 / ethanol View Scheme
参考文献
Nettekoven, Matthias; Jenny, Christian
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 38 - 43
反应条件
1: PBr5 / CCl4 2: 90 percent / NH2NH2 / ethanol 3: 90 percent / aq. NaNO2; aq. HCl View Scheme
参考文献
Nettekoven, Matthias; Jenny, Christian
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 38 - 43
反应条件
1: chelidamic acid With thionyl chloride Reflux; 2: methanol T=0 - 20°C; 2 h;
参考文献
Mueller, Sebastian; Sanders, Deborah A.; Di Antonio, Marco; Matsis, Stephanos; Riou, Jean-Francois; Rodriguez, Raphael; Balasubramanian, Shankar
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 32 p. 6537 - 6546
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2005/51387 A1, 2005 ;
Location in patent: Page/Page column 46; 50 ;
WO 2005/051387 A1
反应条件
sulfuric acid 24 h; Heating;
参考文献
Inouye, Masahiko; Miyake, Toshiyuki; Furusyo, Masaru; Nakazumi, Hiroyuki
Journal of the American Chemical Society, 1995 , vol. 117, # 50 p. 12416 - 12425
反应条件
1: 70 percent / H2SO4 / 24 h / Heating 2: 70 percent / KOH / ethanol / 4 h / Ambient temperature View Scheme
参考文献
Inouye, Masahiko; Miyake, Toshiyuki; Furusyo, Masaru; Nakazumi, Hiroyuki
Journal of the American Chemical Society, 1995 , vol. 117, # 50 p. 12416 - 12425
反应条件
tetrabutylammomium bromide; phosphorus pentoxide in toluene T=100°C; 1 h;
参考文献
Kato, Yoshiaki; Okada, Shigemitsu; Tomimoto, Koji; Mase, Toshiaki
Tetrahedron Letters, 2001 , vol. 42, # 29 p. 4849 - 4851
反应条件
1: chelidamic acid With phosphorus pentabromide T=100 - 120°C; 3 h; 2: methanol T=0°C;
参考文献
Medical Research Council; University of Otago
Patent: US2004/29851 A1, 2004 ;
Location in patent: Page/Page column 7-8 ;
