4-羟基-3-甲基苯甲酸合成路线 （共 31 条）
反应条件
copper; β-cyclodextrin in potassium hydroxide T=80°C; 15 h;
参考文献
Komiyama; Hirai
Journal of the American Chemical Society, 1984 , vol. 106, # 1 p. 174 - 178
反应条件
hydrogen bromide in water; acetic acid T=120°C; 24 h;
参考文献
ASTEX THERAPEUTICS LIMITED
Patent: WO2007/72041 A1, 2007 ;
Location in patent: Page/Page column 57 ;
WO 2007/072041 A1
反应条件
copper in potassium hydroxide T=80°C; 15 h;
参考文献
Schall
Chemische Berichte, 1879 , vol. 12, p. 818,821
参考文献
King; McWhirter; Barton
Journal of the American Chemical Society, 1945 , vol. 67, p. 2089,2090
反应条件
1: AlCl3 / 120 - 130 °C 2: iodine 3: aq. NaOH solution; aq.-ethanolic NaOH-solution View Scheme
参考文献
King; McWhirter; Barton
Journal of the American Chemical Society, 1945 , vol. 67, p. 2089,2090
反应条件
1: iodine 2: aq. NaOH solution; aq.-ethanolic NaOH-solution View Scheme
参考文献
King; McWhirter; Barton
Journal of the American Chemical Society, 1945 , vol. 67, p. 2089,2090
反应条件
sodium hydroxide; copper T=80°C; 5 h;
参考文献
Gaonkar, A. V.; Kirtany, J. K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1991 , vol. 30, # 8 p. 800 - 801
反应条件
potassium hydroxide beim Schmelzen;
参考文献
Lock
Chemische Berichte, 1930 , vol. 63, p. 551,557
反应条件
T=350°C; in der Kalischmelze;
参考文献
Cox
Journal of the American Chemical Society, 1927 , vol. 49, p. 1029
反应条件
potassium hydroxide beim Schmelzen;
参考文献
Jacobsen
Chemische Berichte, 1881 , vol. 14, p. 2356
