2-Boc-6-甲氧基-3,4-二氢-1H-异喹啉-1-羧酸合成路线 （共 2 条）
反应条件
1: With sodium hydroxide; water in tetrahydrofuran; methanol
25 h;
2: With hydrogenchloride in tetrahydrofuran; methanol; water
参考文献
Bristol-Myers Squibb Co.
Patent: US6649606 B1, 2003 ;
Location in patent: Page/Page column 168 ;
US 6649606 B1
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C
1.2: 16 h / 20 °C
2.1: lithium hydroxide hydrate; methanol / tetrahydrofuran / 12 h
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; ORWAT, Michael J.; PINTO, Donald J.P.; SMITH II, Leon M.; SRIVASTAVA, Shefali; CORTE, James R.
Patent: WO2013/55984 A1, 2013 ;
