6-甲酰基-(9CI)-2-吡啶羧酸合成路线 （共 5 条）
反应条件
ozone in methanol; dichloromethane
T=-78°C;
参考文献
KUDOS PHARMACEUTICALS LIMITED
Patent: WO2006/21801 A1, 2006 ;
Location in patent: Page/Page column 43-44 ;
WO 2006/021801 A1
反应条件
potassium hydroxide in tetrahydrofuran
参考文献
CHONG KUN DANG PHARMACEUTICAL CORP.
Patent: WO2004/37808 A1, 2004 ;
Location in patent: Page 9-10 ;
反应条件
1: 85 percent / NaBH4 / methanol / 4 h / 20 °C
2: 74 percent / MnO2 / acetone
3: 72 percent / aq. KOH / tetrahydrofuran
View Scheme
参考文献
Jew, Sang-Sup; Park, Boon-Saeng; Lim, Doo-Yeon; Kim, Myoung Goo; Chung, In Kwon; Kim, Joo Hee; Hong, Chung Il; Kim, Joon-Kyum; Park, Hong-Jun; Lee, Jun-Hee; Park, Hyeung-Geun
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 4 p. 609 - 612
反应条件
1: 74 percent / MnO2 / acetone
2: 72 percent / aq. KOH / tetrahydrofuran
View Scheme
参考文献
Jew, Sang-Sup; Park, Boon-Saeng; Lim, Doo-Yeon; Kim, Myoung Goo; Chung, In Kwon; Kim, Joo Hee; Hong, Chung Il; Kim, Joon-Kyum; Park, Hong-Jun; Lee, Jun-Hee; Park, Hyeung-Geun
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 4 p. 609 - 612
反应条件
1: 100 percent / SOCl2 / 3 h / Heating
2: 85 percent / NaBH4 / methanol / 4 h / 20 °C
3: 74 percent / MnO2 / acetone
4: 72 percent / aq. KOH / tetrahydrofuran
View Scheme
参考文献
Jew, Sang-Sup; Park, Boon-Saeng; Lim, Doo-Yeon; Kim, Myoung Goo; Chung, In Kwon; Kim, Joo Hee; Hong, Chung Il; Kim, Joon-Kyum; Park, Hong-Jun; Lee, Jun-Hee; Park, Hyeung-Geun
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 4 p. 609 - 612
