4-硝基吲哚-2-羧酸乙酯合成路线 （共 16 条）
反应条件
1: With sodium hydroxide; water
Heating / reflux;
2: With hydrogenchloride in water
T=20°C; pH=1 - 2;
参考文献
Hadida Ruah, Sara S.; Grootenhuis, Peter D.J.; Van Goor, Frederick; Zhou, Jinglan; Bear, Brian; Miller, Mark T.; McCartney, Jason; Numa, Mehdi Michel Jamel
Patent: US2007/244159 A1, 2007 ;
Location in patent: Page/Page column 139 ;
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
参考文献
Parmerter et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 4621
反应条件
1: 83 percent / hydrogen / PtO2 / ethanol; tetrahydrofuran / 3.25 h / 724.01 Torr
2: 48 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 48 h
3: 78 percent / aq. NaOH / methanol; dimethylformamide / 0.5 h / 40 - 50 °C
4: 72 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 72 h / Ambient temperature
5: (dimethylamino)pyridine / pyridine / 0.17 h / Ambient temperature
6: 1.) trimethylsilyl chloride, NaI, 2.) triethylamine / 1.) acetonitrile, benzonitrile, 65 deg C, 45 min, reflux, 15 min
View Scheme
参考文献
Warpehoski; Gebhard; Kelly; Krueger; Li; McGovren; Prairie; Wicnienski; Wierenga
Journal of Medicinal Chemistry, 1988 , vol. 31, # 3 p. 590 - 603
反应条件
NaOH; LiAlH4 in tetrahydrofuran; water
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: 9 g / K / dioxane / 1 h / Heating
2: 77 percent / Raney nickel / methanol / 8 h
View Scheme
参考文献
Katti, H. A.; Siddappa, S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 12 p. 1205 - 1208
