反应条件
1.1: water; sodium hydroxide / 3 h / 100 °C / Inert atmosphere 2.1: sulfuric acid / 48 h / Reflux; Inert atmosphere 3.1: caesium carbonate / dimethyl sulfoxide / 24 h / 20 °C / Inert atmosphere 4.1: iron; ammonium chloride / methanol; water / 24 h / 90 °C 5.1: lithium hydroxide hydrate / tetrahydrofuran; methanol; water / 6 h / 75 °C 5.2: pH 7 6.1: V methoxymethyl ester / 24 h / 130 °C / Inert atmosphere 6.2: 20 °C View Scheme
参考文献
Helal, Christopher J.; Kang, Zhijun; Hou, Xinjun; Pandit, Jayvardhan; Chappie, Thomas A.; Humphrey, John M.; Marr, Eric S.; Fennell, Kimberly F.; Chenard, Lois K.; Fox, Carol; Schmidt, Christopher J.; Williams, Robert D.; Chapin, Douglas S.; Siuciak, Judith; Lebel, Lorraine; Menniti, Frank; Cianfrogna, Julia; Fonseca, Kari R.; Nelson, Frederick R.; O Connor, Rebecca; MacDougall, Mary; McDowell, Laura; Liras, Spiros
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4536 - 4547
