hydrogen; palladium in acetic acid P=760 Torr; 12 h; Ambient temperature;

palladium on activated charcoal; perchloric acid; acetic acid Hydrogenation;

1: 84.5 percent / Na-borohydride / methanol / 2 h / Ambient temperature 2: 80.9 percent / 0.83 h / 190 - 200 °C / vacuo 3: 80 percent / H2 / Pd / acetic acid / 12 h / 760 Torr / Ambient temperature View Scheme

1: 1.) NaH / 1.) THF, 0 deg C, 20 min; 2.) THF, room temp., 4 h 2: 91 percent / H2 / Pd / ethyl acetate; methanol / 10 h / 760 Torr 3: 97 percent / NaOH (20percent aq.) / methanol / 3 h / Heating 4: 68 percent / trifluoroacetic anhydride / trifluoroacetic acid / 10 h / Ambient temperature 5: 84.5 percent / Na-borohydride / methanol / 2 h / Ambient temperature 6: 80.9 percent / 0.83 h / 190 - 200 °C / vacuo 7: 80 percent / H2 / Pd / acetic acid / 12 h / 760 Torr / Ambient temperature View Scheme

1: 68 percent / trifluoroacetic anhydride / trifluoroacetic acid / 10 h / Ambient temperature 2: 84.5 percent / Na-borohydride / methanol / 2 h / Ambient temperature 3: 80.9 percent / 0.83 h / 190 - 200 °C / vacuo 4: 80 percent / H2 / Pd / acetic acid / 12 h / 760 Torr / Ambient temperature View Scheme

1: 91 percent / H2 / Pd / ethyl acetate; methanol / 10 h / 760 Torr 2: 97 percent / NaOH (20percent aq.) / methanol / 3 h / Heating 3: 68 percent / trifluoroacetic anhydride / trifluoroacetic acid / 10 h / Ambient temperature 4: 84.5 percent / Na-borohydride / methanol / 2 h / Ambient temperature 5: 80.9 percent / 0.83 h / 190 - 200 °C / vacuo 6: 80 percent / H2 / Pd / acetic acid / 12 h / 760 Torr / Ambient temperature View Scheme

1: 97 percent / NaOH (20percent aq.) / methanol / 3 h / Heating 2: 68 percent / trifluoroacetic anhydride / trifluoroacetic acid / 10 h / Ambient temperature 3: 84.5 percent / Na-borohydride / methanol / 2 h / Ambient temperature 4: 80.9 percent / 0.83 h / 190 - 200 °C / vacuo 5: 80 percent / H2 / Pd / acetic acid / 12 h / 760 Torr / Ambient temperature View Scheme

potassium hydroxide; hydrazine hydrate; ethylene glycol Behandeln des Reaktionsprodukts mit Dimethylsulfat und wss. NaOH;

1: aqueous methanol.KOH 2: palladium/charcoal; ethanol; aqueous HClO4 / Hydrogenation 3: palladium/charcoal; acetic acid; aqueous HClO4 / Hydrogenation View Scheme

phosphorus pentoxide; xylene Hydrieren des Reaktionsprodukts an Palladium/Kohle in Essigsaeure;