反应条件
1: 4-cyano-1-piperidinecarboxylic acid,1,1-dimethyl-ethylester With lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 1 h;
2: formaldehyd in tetrahydrofuran
T=-78 - 20°C; 18 h;
参考文献
Gilbert, Eric J.; Zhou, Guowei; Wong, Michael K.C.; Tong, Ling; Shankar, Bandarpalle B.; Huang, Chunli; Kelly, Joseph; Lavey, Brian J.; McCombie, Stuart W.; Chen, Lei; Rizvi, Razia; Dong, Youhao; Shu, Youheng; Kozlowski, Joseph A.; Shih, Neng-Yang; Hipkin, R. William; Gonsiorek, Waldemar; Malikzay, Asra; Lunn, Charles A.; Favreau, Len; Lundell, Daniel J.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 2 p. 608 - 611
