反应条件
1: 1-methylguanidine hydrochloride With sodium hydroxide in ethanol T=20°C; 16 h; 2: (E)-4-ethoxy-1,1,1-trifluoro-3-buten-2-one in ethanol; dichloromethane T=20°C; 2 h;
参考文献
Goodacre, Simon C.; Street, Leslie J.; Hallett, David J.; Crawforth, James M.; Kelly, Sarah; Owens, Andrew P.; Blackaby, Wesley P.; Lewis, Richard T.; Stanley, Joanna; Smith, Alison J.; Ferris, Pushpinder; Sohal, Bindi; Cook, Susan M.; Pike, Andrew; Brown, Nicola; Wafford, Keith A.; Marshall, George; Castro, Jose L.; Atack, John R.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 1 p. 35 - 38