盐酸胍合成路线 - 魔法化学

参考文献

FMC Corporation
Patent: US5521192 A1, 1996 ;

2032-34-0氰基乙醛缩二乙醇+

参考文献

Otzen, Thomas; Wempe, Ellen G.; Kunz, Brigitte; Bartels, Rainer; Lehwark-Yvetot, Gudrun; Haensel, Wolfram; Schaper, Klaus-Juergen; Seydel, Joachim K.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 1 p. 240 - 253

50-01-1盐酸胍+

123-06-8乙氧基亚甲基丙二腈

16462-27-42,4-二氨基嘧啶-5-腈

参考文献

Karoli, Tomislav; Mamidyala, Sreeman K.; Zuegg, Johannes; Fry, Scott R.; Tee, Ernest H.L.; Bradford, Tanya A.; Madala, Praveen K.; Huang, Johnny X.; Ramu, Soumya; Butler, Mark S.; Cooper, Matthew A.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2428 - 2433

83643-84-9三氟乙酰乙酸甲酯+

50-01-1盐酸胍

1513-69-52-氨基-4-羟基-6-(三氟甲基)嘧啶

参考文献

Savall, Brad M.; Chavez, Frank; Tays, Kevin; Dunford, Paul J.; Cowden, Jeffery M.; Hack, Michael D.; Wolin, Ronald L.; Thurmond, Robin L.; Edwards, James P.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 6 p. 2429 - 2439

50-01-1盐酸胍+

372-31-6三氟乙酰乙酸乙酯

1513-69-52-氨基-4-羟基-6-(三氟甲基)嘧啶

参考文献

Hamprecht, Gerhard; Mayer, Horst; Westphalen, Karl-Otto; Walter, Helmut
Pesticide Science, 1999 , vol. 55, # 5 p. 566 - 570

50-01-1盐酸胍+

774-40-3扁桃酸乙酯

2152-34-3匹莫林

参考文献

Plisson, Fabien; Prasad, Pritesh; Xiao, Xue; Piggott, Andrew M.; Huang, Xiao-Cong; Khalil, Zeinab; Capon, Robert J.
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 10 p. 1579 - 1584

19747-79-6+

50-01-1盐酸胍

119294-45-0

参考文献

Kelarev, V. I.; Karakhanov, R. A.; Bellul', M.; Ushakova, R. L.; Mikaya, A. I.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1988 , p. 550 - 555
Khimiya Geterotsiklicheskikh Soedinenii, 1988 , vol. 24, # 5 p. 674 - 680

3939-09-12,4-双氟苯甲腈+

50-01-1盐酸胍

119584-78-0

参考文献

Huang, Kenneth He; Veal, James; Barta, Thomas; Smith, Emilie D.; Ma, Wei; Ommen, Andy
Patent: US2008/70935 A1, 2008 ;
Location in patent: Page/Page column 46 ;

1221153-85-0+

50-01-1盐酸胍

1221153-78-14-(1-异丙基-1H-吡咯并[2,3-c]吡啶-3-基)嘧啶-2-胺

参考文献

MERCK SHARP andamp; DOHME CORP.; BANYU PHARMACEUTICAL CO., LTD.; GOTO, Yasuhiro; SAGARA, Takeshi; FAN, Weiming; HAXELL, Thomas, F. N.; JENKS, Matthew, G.; MALASKA, Michael, J.; MOORE, Joseph, A., III; OUVRY, Gilles; PANDI, Bharathi; PEEL, Michael, R.; STEWARD, Kimberly, M.
Patent: WO2010/42337 A1, 2010 ;
Location in patent: Page/Page column 46; 48 ;
WO 2010/042337 A1

50-01-1盐酸胍

56-03-1双胍

参考文献

Bamberger, E.; Dieckmann, W.
Ber. Dtsch. Chem. Ges., 1892 , vol. 25, p. 543 - 546
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Gmelin Handbook: C: MVol.D1, 49.5.2, page 472 - 472