反应条件
1: (2,5-diphenyl-1H-pyrrol-1-yl)acetic acid With 1,1'-carbonyldiimidazole in N,N-dimethyl-formamide
T=20°C; 1 h;
2: 1-methylguanidine hydrochloride With triethylamine in N,N-dimethyl-formamide
T=20°C; 5 h; Further stages.;
参考文献
Cole, Derek C.; Stock, Joseph R.; Chopra, Rajiv; Cowling, Rebecca; Ellingboe, John W.; Fan, Kristi Y.; Harrison, Boyd L.; Hu, Yun; Jacobsen, Steve; Jennings, Lee D.; Jin, Guixian; Lohse, Peter A.; Malamas, Michael S.; Manas, Eric S.; Moore, William J.; O'Donnell, Mary-Margaret; Olland, Andrea M.; Robichaud, Albert J.; Svenson, Kristine; Wu, JunJun; Wagner, Eric; Bard, Jonathan
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 3 p. 1063 - 1066