反应条件
1: 1.) diisobutylaluminum hydride, 2.) conc. HCl / 1.) toluene, hexane, -78 deg C, 1.5 h, 2.) THF, -78 deg C, 5 min 2: 1.) n-BuLi/N-isopropylcyclohexylamine / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, -78 deg C, 2 h 3: bromine, triphenyl phosphite / benzene / 1 h / Ambient temperature 4: sodium borohydride, tri-n-butyltin chloride / ethanol / 1.) room temp., 30 min, 2.) reflux, 45 min 5: KOH / ethanol / 1 h / Heating 6: 84 percent / HF (g) 7: 96 percent / sodium borohydride / ethanol / 1.83 h / 55 - 60 °C 8: 93 percent / glacial acetic acid, conc. HCl / 0.25 h 9: 60 percent / 10percent palladium on charcoal / 300 - 305 °C View Scheme
参考文献
Klassen; Daub; Vanderjagt
Journal of Organic Chemistry, 1983 , vol. 48, # 23 p. 4361 - 4366
