5-氨基-2-羟基苯乙酮合成路线 （共 14 条）
参考文献
Elliott; Selnick; Claremon; Baldwin; Buhrow; Butcher; Habecker; King; Lynch Jr.; Phillips; Ponticello; Radzilowski; Remy; Stein; White; Young
Journal of Medicinal Chemistry, 1992 , vol. 35, # 21 p. 3973 - 3976
反应条件
hydrogen; palladium on activated charcoal in tetrahydrofuran P=2068.6 Torr; 2 h;
参考文献
Cushman, Mark; Zhu, Helen; Geahlen, Robert L.; Kraker, Alan J.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3353 - 3362
反应条件
1: 33 percent / nitric acid, glacial acetic acid / 1.) RT, 40 min, 2.) from 45 to 50 deg C, 16 h 2: hydrogen / 5percent Pd/C / tetrahydrofuran / 2 h / 2068.6 Torr View Scheme
参考文献
Cushman, Mark; Zhu, Helen; Geahlen, Robert L.; Kraker, Alan J.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3353 - 3362
反应条件
1: 87 percent / AlCl3 / CH2Cl2 2: 99 percent / aq. HCl View Scheme
参考文献
Elliott; Selnick; Claremon; Baldwin; Buhrow; Butcher; Habecker; King; Lynch Jr.; Phillips; Ponticello; Radzilowski; Remy; Stein; White; Young
Journal of Medicinal Chemistry, 1992 , vol. 35, # 21 p. 3973 - 3976
反应条件
1: 90 percent / CH2Cl2 2: 87 percent / AlCl3 / CH2Cl2 3: 99 percent / aq. HCl View Scheme
参考文献
Elliott; Selnick; Claremon; Baldwin; Buhrow; Butcher; Habecker; King; Lynch Jr.; Phillips; Ponticello; Radzilowski; Remy; Stein; White; Young
Journal of Medicinal Chemistry, 1992 , vol. 35, # 21 p. 3973 - 3976
反应条件
1: 62 percent / AlCl3 / nitrobenzene / 3 h / 20 - 130 °C 2: 86 percent / 15percent HCl View Scheme
参考文献
Kettmann; Csollei; Racanska; Svec
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 9 p. 843 - 851
反应条件
sulfuric acid Electrolysis;
参考文献
Gattermann
Chemische Berichte, 1896 , vol. 29, p. 3039
反应条件
1: aluminium chloride; carbon disulfide / Irradiation 2: concentrated hydrochloric acid View Scheme
参考文献
Kunckell
Chemische Berichte, 1901 , vol. 34, p. 125
反应条件
Diazotization.und Verkochen;
参考文献
Lindemann; Romanoff
Journal fuer Praktische Chemie (Leipzig), 1929 , vol. <2>122, p. 215,220,225
反应条件
1: tetrahydrofuran / 0.33 h / 60 °C 2: 71 percent / nitric acid, glacial acetic acid / 2 h / Ambient temperature 3: 96 percent / methanol; H2O / 1 h / 85 °C 4: 90 percent / NaNO2, H2SO4 / ethanol; H2O / 1.) from 0 to 5 deg C, 20 min, 2.) 85 deg C, 20 min, 3.) RT, 1 h View Scheme
参考文献
Cushman, Mark; Zhu, Helen; Geahlen, Robert L.; Kraker, Alan J.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3353 - 3362
