反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C
1.2: 18 h / 60 °C
2.1: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / tetrachloromethane / 18 h / |Reflux
3.1: nitromethane; sodium methylate / methanol / |Inert atmosphere; |Reflux
View Scheme
参考文献
Zimmerman, Sommer S.; Khatri, Alpa; Garnier-Amblard, Ethel C.; Mullasseril, Praseeda; Kurtkaya, Natalie L.; Gyoneva, Stefka; Hansen, Kasper B.; Traynelis, Stephen F.; Liotta, Dennis C.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 6 p. 2334 - 2356