1.1: 60 percent / NBS; benzoyl peroxide / CCl4 / 1 h / 70 °C 2.1: LDA / toluene; tetrahydrofuran; hexane / 2 h / -78 °C 2.2: tetrahydrofuran; toluene; hexane / 3 h / -78 - 0 °C 3.1: 82.0 mg / tetrabutylammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C 4.1: 55 percent / SnCl4 / CH2Cl2 / 1 h / 0 °C 5.1: splG; DTT; KCl / (S)-adenosylmethionine / various solvent(s) / 12 h / 4 °C View Scheme
参考文献
Friedel, Marcus G.; Pieck, J. Carsten; Klages, Jochen; Dauth, Christina; Kessler, Horst; Carell, Thomas
Chemistry - A European Journal, 2006 , vol. 12, # 23 p. 6081 - 6094
1.1: LDA / toluene; tetrahydrofuran; hexane / 2 h / -78 °C 1.2: tetrahydrofuran; toluene; hexane / 3 h / -78 - 0 °C 2.1: 82.0 mg / tetrabutylammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C 3.1: 55 percent / SnCl4 / CH2Cl2 / 1 h / 0 °C 4.1: splG; DTT; KCl / (S)-adenosylmethionine / various solvent(s) / 12 h / 4 °C View Scheme
参考文献
Friedel, Marcus G.; Pieck, J. Carsten; Klages, Jochen; Dauth, Christina; Kessler, Horst; Carell, Thomas
Chemistry - A European Journal, 2006 , vol. 12, # 23 p. 6081 - 6094
Liang, Fengting; Jain, Nidhi; Hutchens, Troy; Shock, David D.; Beard, William A.; Wilson, Samuel H.; Chiarelli, M. Paul; Cho, Bongsup P.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 20 p. 6460 - 6470
