5-氟-2'-脱氧脲核苷合成路线 （共 43 条）
反应条件
T=37°C; pH=7.4; aq. phosphate buffer; Kinetics; pH-value;
参考文献
Ge, Yiyu; Wu, Xinghua; Zhang, Dazhi; Hu, Longqin
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 3 p. 941 - 944
反应条件
T=37°C; pH=7.4; aq. phosphate buffer; Kinetics; pH-value;
参考文献
Ge, Yiyu; Wu, Xinghua; Zhang, Dazhi; Hu, Longqin
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 3 p. 941 - 944
反应条件
in acetic acid different solvents (AcOH,H2O), various nucleosides; Product distribution;
参考文献
Visser, Gerard W. M.; Herder, Renella E.; Noordhuis, Paul; Zwaagstra, Oene; Herscheid, Jacobus D. M.; Kanter, Frans J. J. de
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 2547 - 2554
反应条件
recombinant thymidine phosphorylase from Mycoplasma hyorhinis T=37°C; 0.333333 h; aq. bufferEnzymatic reaction; Kinetics;
参考文献
NUCANA BIOMED LIMITED; MCGUIGAN, Christopher; BALZARINI, Jan; SLUSARCYZK, Magdalena; GONCZY, Blanka; MURZIANI, Paola
Patent: WO2012/117246 A1, 2012 ;
Location in patent: Page/Page column 65 ;
WO 2012/117246 A1
反应条件
Escherichia coli recombinant thymidine phosphorylase; water T=20°C; aq. bufferEnzymatic reaction;
参考文献
Vande Voorde, Johan; Liekens, Sandra; McGuigan, Christopher; Murziani, Paola G.S.; Slusarczyk, Magdalena; Balzarini, Jan
Biochemical Pharmacology, 2011 , vol. 82, # 5 p. 441 - 452
反应条件
PSL-C; [BMMIM][PF6] in tetrahydrofuran T=50°C; 66 h; Reactivity; TimeTemperature; regioselective reaction;
参考文献
Li, Ning; Zong, Min-Hua; Ma, Ding
Tetrahedron, 2009 , vol. 65, # 5 p. 1063 - 1068
反应条件
pyridine 1 h; Heating;
参考文献
Stuart; Ayisi; Tourigny; Gupta
Journal of Pharmaceutical Sciences, 1985 , vol. 74, # 3 p. 246 - 249
反应条件
1: diphenyl sulfite, 1-methylimidazole / N,N-dimethyl-acetamide / 0.33 h / 155 °C 2: 74 percent / NaH / N,N-dimethyl-acetamide / 0.5 h / 100 °C View Scheme
参考文献
Joshi, Bhalchandra V.; Rao, T. Sudhakar; Reese, Colin B.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 19 p. 2537 - 2544
反应条件
Candida antarctica lipase B in acetone T=40°C; 4 h; Enzymatic reaction; regioselective reaction;
参考文献
Li, Ning; Zong, Min-Hua; Ma, Ding
European Journal of Organic Chemistry, 2008 , # 32 p. 5375 - 5378
反应条件
1: DMAP / pyridine 2: POCl3 3: pyridine 4: NH3 / methanol 5: DMAP / pyridine 6: (i-Pr)2NH / tetrahydrofuran 7: conc. NH4OH View Scheme
参考文献
MacMillan; Chen; Verdine
Journal of Organic Chemistry, 1992 , vol. 57, # 11 p. 2989 - 2991
