2-溴-3‘-甲氧基苯乙酮合成路线 （共 33 条）
反应条件
bromine in chloroform T=20°C; 4 h;
参考文献
Chimenti, Franco; Bolasco, Adriana; Secci, Daniela; Chimenti, Paola; Granese, Arianna; Carradori, Simone; Yanez, Matilde; Orallo, Francisco; Ortuso, Francesco; Alcaro, Stefano
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 15 p. 5715 - 5723
反应条件
T=100°C; 0.0166667 h; Microwave irradiation;
参考文献
Kaesnaenen, Heikki; Myllymaeki, Mikko J.; Minkkilae, Anna; Kataja, Antti O.; Saario, Susanna M.; Nevalainen, Tapio; Koskinen, Ari M. P.; Poso, Antti
ChemMedChem, 2010 , vol. 5, # 2 p. 213 - 231
反应条件
1: CHCl3 / 8 h / Heating 2: 73 percent / aq. sodium nitrite, glacial acetic acid / 3 h / 0 - 20 °C View Scheme
参考文献
Srivastava, Pratima; Pandey, Vikash Chandra; Misra, Anju Prabha; Gupta, Preeti; Raj, Kanwal; Bhaduri, Amiya Prasad
Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 2 p. 181 - 187
反应条件
1.1: NaN3; CH3N[(CH2)7CH3]3Cl / toluene / 55 °C 2.1: H2; HCl / Pt/C / methanol 3.1: Et3N / tetrahydrofuran / 20 °C 4.1: NaOEt / ethanol / 55 °C 5.1: 80 °C 5.2: NH3 / methanol / 20 °C View Scheme
参考文献
Widler, Leo; Green, Jonathan; Missbach, Martin; Susa, Mira; Altmann, Eva
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 6 p. 849 - 852
反应条件
1: NaN3; CH3N[(CH2)7CH3]3Cl / toluene / 55 °C 2: H2; HCl / Pt/C / methanol 3: Et3N / tetrahydrofuran / 20 °C 4: NaOEt / ethanol / 55 °C View Scheme
参考文献
Widler, Leo; Green, Jonathan; Missbach, Martin; Susa, Mira; Altmann, Eva
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 6 p. 849 - 852
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; CLEVELAND, Thomas; MAKINGS, Lewis R.; HAMILTON, Matthew; GROOTENHUIS, Peter D.J.
Patent: WO2005/26137 A2, 2005 ;
Location in patent: Page/Page column 247-248 ;
WO 2005/026137 A2
反应条件
aluminum oxide; ammonium acetate; silica gel in benzene T=90°C; 16 h;
参考文献
Jung, Kwan-Young; Kim, Soo-Kyung; Gao, Zhan-Guo; Gross, Ariel S.; Melman, Neli; Jacobson, Kenneth A.; Kim, Yong-Chul
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 3 p. 613 - 623
反应条件
1: ethanol With selenium(IV) oxide 0.166667 h; Heating / reflux; 2: 1-bromo-2-(3-methoxyphenyl)-2-oxoethane Heating / reflux;
参考文献
ALMIRALL PRODESFARMA S.A.
Patent: WO2006/122788 A1, 2006 ;
Location in patent: Page/Page column 67-68 ;
WO 2006/122788 A1
反应条件
sodium chloride; tin(ll) chloride in tetrahydrofuran; water 2 h; Heatingfurther sodium halides or pseudo-halides and metal halides;
参考文献
Ono, Aoi; Yamaguchi, Ritsuko; Shirai, Yoshiko
Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1986 , vol. 41, # 12 p. 1568 - 1570
反应条件
in N,N-dimethyl-formamide T=25°C; 0.25 h; Inert atmosphere; Overall yield = 217 mg;
参考文献
Novak, Petr; Lishchynskyi, Anton; Grushin, Vladimir V.
Journal of the American Chemical Society, 2012 , vol. 134, # 39 p. 16167 - 16170
