2-溴-3‘-甲氧基苯乙酮合成路线 （共 33 条）
反应条件
1.1: chloroform; ethanol / 2.5 h / 0 - 20 °C 1.2: 2.5 h / 0 - 20 °C 2.1: triethylamine / dichloromethane / 1 h / 0 °C 3.1: potassium hydroxide / isopropyl alcohol / 20 °C 4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C 5.1: hydrogen; palladium hydroxide on carbon / methanol / 20 °C / |Inert atmosphere View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BROTHERTON-PLEISS, Christine, E.; CHEN, Zhi; ERICKSON, Shawn, David; KIM, Kyungjin; LI, Hongju; QIAN, Yimin; SO, Sung-Sau; WOVKULICH, Peter, Michael; YI, Lin
Patent: WO2014/56958 A1, 2014 ;
反应条件
1-methyl-1H-imidazole in diethyl ether; acetonitrile
参考文献
Eli Lilly and Company
Patent: US4609670 A1, 1986 ;
反应条件
1,4-dioxane; anhydrous sodium borate; water Reagens 4: wss. Schwefelsaeure; Erhitzen des Reaktionsprodukts mit wss. Kalilauge;
参考文献
Perrone, Roberto; Berardi, Francesco; Leopoldo, Marcello; Tortorella, Vincenzo; Lograno, Marcello D.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 16 p. 3045 - 3049
反应条件
sodium tetrahydroborate; CsCO3; ammonium chloride; palladium on charcoal in methanol; acetonitrile
参考文献
Moran, Edmund J.; Fournier, Eric
Patent: US2004/6102 A1, 2004 ;
US 20040006102 A1
反应条件
1: With boron tribromide in dichloromethane T=-10°C; 1.5 h; 2: With water in dichloromethane T=0°C;
参考文献
US2005/239843 A1, ;
Page/Page column 55 ;
反应条件
1: p-TsOH / methanol / 4 h 2: AgBF4 / methanol / 22 h / 40 °C View Scheme
参考文献
Giordano, Claudio; Castaldi, Graziano; Casagrande, Francesco; Belli, Aldo
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 11 p. 2575 - 2582
反应条件
1: p-TsOH / methanol / 4 h 2: AgBF4 / methanol / 22 h / 40 °C 3: aq. NaOH / methanol / 4 h / Ambient temperature View Scheme
参考文献
Giordano, Claudio; Castaldi, Graziano; Casagrande, Francesco; Belli, Aldo
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 11 p. 2575 - 2582
参考文献
Kamila, Sukanta; Zhu, Dunming; Biehl, Edward R.; Hua, Ling
Organic Letters, 2006 , vol. 8, # 20 p. 4429 - 4431
反应条件
sodium tetrahydroborate; CsCO3; ammonium chloride; palladium on charcoal in methanol; acetonitrile
参考文献
Moran, Edmund J.; Fournier, Eric
Patent: US2004/6102 A1, 2004 ;
US 20040006102 A1
反应条件
sodium tetrahydroborate; CsCO3; ammonium chloride; palladium on charcoal in methanol; acetonitrile
参考文献
Moran, Edmund J.; Fournier, Eric
Patent: US2004/6102 A1, 2004 ;
US 20040006102 A1
