2-溴-3‘-甲氧基苯乙酮合成路线 （共 33 条）
反应条件
in toluene
24 h; Heating / reflux;
参考文献
Heil, Markus; Meier, Heinrich; Naab, Paul; Voerste, Arnd; de Vry, Jean-Marie-Viktor; Denzer, Dirk; Mauler, Frank; Lustig, Klemens; Hinz, Volker; Allerheiligen, Swen
Patent: US2003/232802 A1, 2003 ;
Location in patent: Page 19 ;
反应条件
1.1: acetone / Heating
1.2: aq. K2CO3
2.1: NaSEt / dimethylformamide / 100 °C
View Scheme
参考文献
Chai, Wenying; Breitenbucher, J. Guy; Kwok, Annette; Li, Xiaobing; Wong, Victoria; Carruthers, Nicholas I.; Lovenberg, Timothy W.; Mazur, Curt; Wilson, Sandy J.; Axe, Frank U.; Jones, Todd K.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 10 p. 1767 - 1770
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C;
参考文献
Wang, You-Qing; Lu, Sheng-Mei; Zhou, Yong-Gui
Organic Letters, 2005 , vol. 7, # 15 p. 3235 - 3238
反应条件
1: in acetone
Heating;
2: With potassium carbonate
参考文献
Apodaca, Richard; Carruthers, Nicholas I.; Carson, John R.; Chai, Wenying; Kwok, Annette K.; Li, Xiaobing; Lovenberg, Timothy W.; Rudolph, Dale A.; Shah, Chandravadan R.
Patent: US2003/13733 A1, 2003 ;
反应条件
1: acetone / Heating
2: K2CO3 / H2O / Heating
View Scheme
参考文献
Lins; Block; Doerge
Journal of Pharmaceutical Sciences, 1982 , vol. 71, # 5 p. 556 - 561
反应条件
1: 90 percent / acetonitrile; dimethylformamide / 14 h / 90 °C
2: 50 percent / imidazole / 14 h / 180 °C
View Scheme
参考文献
CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); PASTOR FERNANDEZ, Joaquin; MARTINEZ GONZALEZ, Sonia; ALVAREZ ESCOBAR, Rosa Maria; RODRIGUEZ HERGUETA, Antonio; MARTIN HERNANDO, Jose Ignacio; RAMOS LIMA, Francisco, Javier
Patent: WO2011/89400 A1, 2011 ;
WO 2011/089400 A1
反应条件
1: 54 percent / KHF2 / various solvent(s) / 3 h / 100 °C
2: 80 percent / NaH / toluene / 0.5 h / < 15 deg C
View Scheme
参考文献
McDonald, Ian A.; Lacoste, Jean Michel; Bey, Philippe; Wagner, Joseph; Zreika, Monique; Palfreyman, Michael G.
Journal of the American Chemical Society, 1984 , vol. 106, # 11 p. 3354 - 3356
反应条件
N,N-dimethyl-aniline
T=170°C;
参考文献
Kaufmann, Doris; Pojarova, Michaela; Vogel, Susanne; Liebl, Renate; Gastpar, Robert; Gross, Dietmar; Nishino, Tsuyuki; Pfaller, Tobias; von Angerer, Erwin
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 15 p. 5122 - 5136
反应条件
sodium ethanolate in ethanol
Ambient temperature;
参考文献
Dattolo, Gaetano; Cirrincione, Girolamo; Almerico, Anna Maria; Presti, Giuseppe; Aiello, Enrico
Heterocycles, 1984 , vol. 22, # 10 p. 2269 - 2276
反应条件
1.1: dichloromethane / 20 °C
2.1: methanol; water / 1 h / 20 °C
2.2: 20 °C / pH 7 - 8
View Scheme
参考文献
An, Xiao-Lei; Chen, Jia-Rong; Li, Chang-Feng; Zhang, Fu-Gen; Zou, You-Quan; Guo, Ying-Cen; Xiao, Wen-Jing
Chemistry - An Asian Journal, 2010 , vol. 5, # 10 p. 2258 - 2265
